The main function of the spleen (red pulp) is to filter the blood, removing worn out blood cells and recycling the proteins and iron. It is also a reserve factory for manufacture of blood cells. In horses and some dogs such as greyhounds, the organ is a reserve for the oxygen-carrying red cells required for sudden bursts of activity. In the white pulp, the spleen contains large numbers of lymphocytes and macrophages, cells of the immune system. These cells are involved in recognizing 'foreign', potentially harmful materials like infectious microorganisms, helping destroy them and then providing protection (immunity) against future attack. Tumors of the spleen are common in older dogs, but rare in cats. In some cases, the enlargement may be due to blood accumulating as a result of poor circulation or bleeding within the spleen (hematoma). 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Determining for certain whether a patient has canine Addison’s disease is difficult because the clinical signs are vague and mimic those of other diseases that can often be temporarily resolved with fluids and other supportive care. Most of these stones are composed of the mineral salts of common elements found in our bodies, calcium, magnesium, ammonia, phosphorus and carbonates. Their composition and consistency are similar to that of limestone. Several things contribute to the formation of urinary tract stones. If the concentration of mineral salts are too high in the urine, they precipitate out, layer upon layer. This can happen in the kidneys or farther down the tract in the bladder. The urine of dogs and cats should be naturally acidic. Most mineral salts are less soluble in alkaline urine so any factors that make the urine more basic or alkaline contribute to stone formation. 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