Water pills, also known as diuretics, are medications designed to reduce the amount of water and sodium in the body. They are used for a variety of conditions, including swelling due to fluid build-up, congestive heart failure, high blood pressure, glaucoma and certain kidney or liver diseases. Three main types of water pills are available: thiazide diuretics, loop diuretics and potassium-sparing diuretics. Although the mechanisms by which they work are different, the three types have several side effects in common, as well as some unique side effects. Diuretics can affect the amount of potassium, sodium and chloride in the bloodstream. Thiazide and loop diuretics often lower blood levels of potassium unless people consume extra amounts of potassium-rich foods. 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