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Fluconazole chemical structure

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    Fluconazole chemical structure


    Antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. how to order lasix online Fluconazole is a first-generation triazole antifungal medication. It differs from earlier azole antifungals (such as ketoconazole) in that its structure contains a triazole ring instead of an imidazole ring. While the imidazole antifungals are mainly used topically, fluconazole and certain other triazole antifungals are preferred when systemic treatment is required because of their improved safety and predictable absorption when administered orally. Fluconazole's spectrum of activity includes most Candida species (but not Candida krusei or Candida glabrata), Cryptococcus neoformans, some dimorphic fungi, and dermatophytes, among others. Common uses include: Fungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection). albicans, resistance occurs by way of mutations in the ERG11 gene, which codes for 14α-demethylase. These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol. glabrata is increasing the rate of efflux of the azole drug from the cell, by both ATP-binding cassette and major facilitator superfamily transporters. Development of resistance to one azole in this way will confer resistance to all drugs in the class. Other gene mutations are also known to contribute to development of resistance.

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    Structure, chemical names, physical and chemical properties, classification. Chemical Names Fluconazole-d4; 1124197-58-5; Biozolene-d4;. metformin er generic Compound Type. Amine; Antifungal Agent; Drug; Metabolite; Organic Compound; Organofluoride; Synthetic Compound. Chemical Structure. Melting point °C, 138-140 °C, 3248 water solubility, slightly soluble in water.

    Fluconazole is only found in individuals that have used or taken this drug. It is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Fluconazole is a novel kind triazole drug of anti-fungal infection which was first successfully developed by the American Pfizer with broad-spectrum anti-fungal effect. It belongs to a kind of systemic anti-fungal products and has high selectivity on the inhibitory effect of the fungal cytochrome P450-dependent enzyme. It is also a kind of potent and specific inhibitor for the fungi alcohol synthesis. Clinically it is mainly used for the treatment of vaginal candidiasis, thrush, atrophic oral candidiasis, fungal meningitis, pulmonary fungal infections, abdominal infections, urinary tract infections and skin fungi infection. The main indication for fluconazole as follows: 1, systemic candidiasis: including candidemia, disseminated candidiasis and other forms of invasive Candida infections such as the peritoneum, endocardium, lungs and urinary tract infections. It can also be applied to patients of malignant tumors, special-care patients, patients who received radiotherapy, chemotherapy or immunosuppressive therapy as well as patients who are susceptible to other factors such as infection of Candida. It can also be used for prevention of the occurrence of candida infection for bone marrow transplant patients upon receiving cytotoxic drugs treatment or radiation treatment.

    Fluconazole chemical structure

    Fluconazole - an overview ScienceDirect Topics -, T3DB Fluconazole

  2. Fluconazole dosage for thrush
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  4. DRUG Fluconazole, Help. Entry. D00322 Drug. Name. Fluconazole JP17/USAN /INN; Fluconazole capsules JP17;. Chemical structure group DG00371.

    • KEGG DRUG Fluconazole
    • Fluconazole DB00196 - Fluconazole - DrugBank
    • Chemical structure of fluconazole Diflucan. Download Scientific.

    Fluconazole Chemical Structure. Molecular WeightMW 306.27. Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the. amoxil Fluconazole ≥98% HPLC, powder; CAS Number 86386-73-4; Synonym 2-2,4-Difluorophenyl-1. Linear Formula C13H12F2N6O; find Sigma-Aldrich-F8929 MSDS, related peer-reviewed papers. plasmid vector for molecular cloning. Fluconazole; 86386-73-4; Diflucan; Triflucan; Elazor; Biozolene More. Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. Fluconazole is an Azole Antifungal. The chemical classification of fluconazole is Azoles.

     
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    If you have ever been prescribed antibiotics for a bacterial infection, you have probably been given amoxicillin or Augmentin (amoxicillin clavulanate) at one time or another. If your child has ever needed antibiotics, both may have been prescribed. Amoxicillin is often the first antibiotic prescribed for common infections like ear infections and strep throat. It is typically used in young children because it is effective against many common childhood bacterial infections and doesn't have many severe side effects. By adding a beta-lactamase blocker to amoxicillin, Augmentin is able to overcome resistance to harder-to-treat bacteria, broadening the spectrum of infections it can treat. It is for this reason that Augmentin is referred to as a broad-spectrum antibiotic. If you have an infection and don't necessarily know which bacteria is causing it, it may seem to make sense to use an antibiotic that would kill the most bugs. Another, even more pressing concern is that using broad spectrum antibiotics can lead to antibiotic resistance. Cephalexin vs Amoxicillin Main Differences and Similarities cipro 750 mg Best Antibiotics for Strep Throat PlushCare Strep Throat HealthLink BC
     
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