The reaction can be phototoxic and/or photoallergic. Phototoxic reactions result from direct damage to tissue caused by light activation of the photosensitising agent, whilst photoallergic reactions are a cell-mediated immune response in which the is the light-activated photosensitising agent. Chloroquine parenteral Plaquenil antimalarial medications Phototoxic reaction This is the most common reaction and usually occurs when a drug you’re taking whether by mouth or topically applied is activated by exposure to UV light and causes damage to the skin that can look and feel like a sunburn or a rash. Hydroxychloroquine has been rarely associated with drug reaction with eosinophilia and systemic symptoms DRESS, but this would not resolve quickly with discontinuation and corticosteroid therapy. 1 In addition, phototoxic and photoallergic dermatitis rarely occur. Phototoxic reaction 1. This is the most common type of sun-sensitivity drugreaction. 2. It can occur when the skin is exposed to the sun after certain medications are injected, ingested, or applied to the skin. 3. It may arise within a few hours or up to a few days after the drug is taken. 4. Although some oral photosensitising medications can cause photoallergic reactions, most cause phototoxic reactions. Photoallergic reactions occur less commonly than phototoxic reactions and are mostly caused by photosensitising topical agents. Phototoxic reaction to plaquenil Photosensitivity Reactions - Skin Disorders - Merck Manuals., Hydroxychloroquine and angioedema AAAAI Seroqul and chloroquinIs 200 milligrams of hydroxychloroquine high Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Phototoxic reaction - DPHHS. Photosensitivity Reaction With Certain Medications. Dec 12, 2019 In a double-blinded study, this drug was found to be more phototoxic than minocycline and demeclocycline. Paresthesias of the body areas exposed to sunlight may be early signs of sunburn reactions. A case report of a possible photoallergic reaction described scaly erythema and vesicles on the face and neck associated with administration of this drug. Summary Photosensitivity reaction is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months, also take medication Humira, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food. Jun 12, 2018 Phototoxic reactions in skin Acute phototoxicity often begins as an exaggerated sunburn reaction with erythema and edema that occurs within minutes to hours of light exposure. Vesicles and bullae may develop with severe reactions.