Long-term progression of hydroxychloroquine retinopathy off the drug marmor

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  1. F3d0R Moderator

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Retinal Toxicity Progression. Severe HCQ retinopathy often progresses even after drug cessation Researchers used multimodal imaging to study retinal and vision changes after hydroxychloroquine HCQ cessation in 22 patients with HCQ retinal toxicity. Pham B, et al. Long-term progression of hydroxychloroquine retinopathy off the drug. Presented at Association for Research in Vision and Ophthalmology annual meeting; April 29-May 3, 2018; Honolulu. Apr 26, 2019 Lally DR, Heier JS, Baumal C, Witkin AJ, Maler S, Shah CP, et al. Expanded spectral domain-OCT findings in the early detection of hydroxychloroquine retinopathy and changes following drug.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    Effect of Disease Stage on Progression of Hydroxychloroquine., Despite Plaquenil dosing recommendations, retinal toxicity.

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  5. Pham BH, Marmor MF. Sequential changes in hydroxychloroquine retinopathy up to 20 years after stopping the drug Implications for Mild Versus Severe Toxicity. Retina. 2019;2–501. CAS; Article

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    We found that a pericentral pattern of HCQ retinopathy was predominant among Korean patients, rather than the traditional bull's eye parafoveal pattern of damage. Retinopathy progressed while on the drug, but the progression stopped in patients with toxicity detected before RPE damage. Concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Monitoring Guidelines. Guidelines on screening for retinopathy associated with hydroxychloroquine toxicity were initially published by the Academy in 2002. IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy.

     
  6. makclit User

    Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine Retinopathy - an overview ScienceDirect Topics Rheumatoid Arthritis Treatment Options Johns Hopkins.
     
  7. Emotion Well-Known Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil and explosive bowel movements - Sjogren's World PLAQUENIL® Omeprazole and Hydroxychloroquine sulfate drug interactions.
     
  8. tonie Guest

    Hydroxychloroquine User Reviews for Rheumatoid Arthritis. User Reviews for Hydroxychloroquine to treat Rheumatoid Arthritis. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.