These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Chloroquine help with payment for prescriptions Hydroxychloroquine long term Is plaquenil a thiopurine drug Serious Side Effects of Plaquenil. If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye;. RARE side effects. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Plaquenil immediate side effects Plaquenil Side Effects Common, Severe, Long Term -, PATIENT FACT SHEET Hydroxychloroquine Plaquenil Chloroquine lysotrackerHow long does plaquenil take to kick inChloroquine phosphate leth These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome. Plaquenil Side Effects - GoodRx. Common and Rare Side Effects for Plaquenil Oral. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. When cut, too much of the drug can be released at once and cause a reaction or side effects. When prescribed 300 mg. daily, you should alternate one tablet one day with two the next. I've been on Plaquenil for almost four years now and it's helped me a lot. What are the side effects of hydroxychloroquine Plaquenil? Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching.