Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine light sensitivity Does plaquenil cause coughing Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito. That is a good suggestion! i'll call them up and see- could split dose between breakfast and lunch or take all in the morning. Continue this thread level 1. 2 points 3 years ago. Have been on Plaquenil for 11 years and have never had issues with sleepwalking-- or any other issues. I would definitely bring this up with your rheumy and see. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Splitting hydroxychloroquine Pill splitting which ones are safe to divide? – Heart Sisters, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Autofluorescence imaging in plaquenilSafe to take plaquenil and estrogen together Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine/plaquenil and sleepwalking lupus. Plaquenil Uses, Dosage & Side Effects -. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Human fingernails typically grow at about 0.1 mm/day toenails grow at half that rate; as nails grow, Beau’s lines move upward and are eventually snipped off. 1,3,4 Onychomadesis—nail shedding or splitting—is an extreme degree of Beau’s lines. 5; Leukonychia, also called milk spots, occurs when drugs affect keratinization. What are hydroxychloroquine Plaquenil and chloroquine Aralen? These medications are in a class of medications called Disease Modifying Anti-Rheumatic Drugs, or DMARDS. DMARDs are a slow acting but effective treatment for rheumatoid arthritis and other forms of inflammatory arthritis.