Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE). The looks of a plaquenil pill Dermatomyositis rash and plaquenil Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Plaquenil ® hydroxychloroquine sulfate can potentially interact with a few other medications. Some of these medicines that may lead to Plaquenil drug interactions include Certain beta blockers, such as Bisoprolol Zebeta ® Metoprolol Lopressor ®, Toprol XL ® Propranolol Inderal ® Sotalol Betapace ® Timolol Blocadren ® Jun 11, 2013 Study Raises Questions about Sjogren's and Plaquenil. For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease. Plaquenil and procedures Hydroxychloroquine Plaquenil Side Effects & Dosage for., Plaquenil Interactions - eMedTV Health Information. Show me a picture of plaquenil Nov 12, 2009 Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. What is the correct way to discontinue use of plaquenil?. Study Raises Questions about Sjogren's and Plaquenil. Can Plaquenil Be Taken Before Or After A Surgery? - Page 5. Other Medical Problems. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially Allergy to 4-aminoquinoline compounds eg, chloroquine—Should not be used in patients with this condition. The surgeon had me check with my rheumy about stopping Plaquenil and I was told to continue it, or just stop it the day of surgery then get right back on, I asked what would happen if I stopped for a week and was told I'd risk going into a flare. I stayed on it and surgery went OK. I agree though, don't take the nurses decision, get it straight. Find information about common, infrequent and rare side effects of Plaquenil Oral.