It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Chloroquine pretreatment degradation toxicity Hydrox chloroquine Plaquenil alopecia The recommended adult dose for rheumatoid arthritis is 400-600 mg daily for 4-12 weeks followed by 200-400 mg daily. Systemic lupus erythematosus is treated with 400 mg once or twice daily for several weeks then 200-400 mg daily. Hydroxychloroquine should be taken with food or milk in order to reduce stomach upset. Hydroxychloroquine is a good drug for mild arthritis however length of time it takes for drug to leave body is worrying when you are faced with loosing your sight and possible progression after you stopped taking the drug. Also check the dose is correct for your ideal weight do you are not over medicated." Generally, hydroxychloroquine is given in 200 mg or 400 mg doses, once per day. Higher doses can sometimes be used, but only in adults and not for all cases. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine 400 mg for rheumatoid arthritis Hydroxychloroquine Reviews Everyday Health, Hydroxychloroquine User Reviews for Rheumatoid Arthritis. Plaquenil revised dosing ANSWER. Hydroxychloroquine Plaquenil and sulfasalazine Azulfidine are used for mild rheumatoid arthritis. They are not as powerful as other DMARDs, but they usually cause fewer side effects. In rare cases, Plaquenil can adversely affect the eyes, and people taking this medicine should be seen by an ophthalmologist at least once a year. What are the side effects of using hydroxychloroquine.. RA and Hydroxychloroquine How Effective is it for.. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti- spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. For the treatment of RA, hydroxychloroquine is typically taken by mouth once daily at 200-400 mg, although it can be taken at a higher dose. A loading dose of 1,200 mg daily, given for 6 weeks may decrease the time to clinical response. However, experts debate that this higher dosage may increase the risk of toxicity.