Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Bacillus Calmette-Guérin (BCG) is a standard treatment option for non-muscle invasive bladder cancer. Merck & Co., the only maker and supplier of BCG to the United States, has informed the Urology Care Foundation that they are now experiencing a global shortage of BCG due the growing use and need for this product around the world. While Merck has raised their production of BCG, they expect this shortage to carry through 2019. The Foundation is very concerned about this medication shortage, and we understand this situation can be stressful for physicians and patients. Food and Drug Administration in identifying and approving other sources of BCG are ongoing. To help minimize disruptions to patient care, the Urology Care Foundation has been working closely with the American Urological Association (AUA), American Association of Clinical Urologists, Bladder Cancer Advocacy Network and the Society of Urologic Oncology to develop strategies to help providers treat patients with bladder cancer while this supply constraint continues. The Urology Care Foundation remains in contact with the AUA and Merck, and will share more news as it becomes available. For further information about BCG, please review Merck’s frequently asked questions or feel free to reach out to their National Service Center at 1-800-444-2080. Non-muscle invasive bladder cancer (NMIBC) is cancer found in the tissue that lines the inner surface of the bladder. Bladder cancer is the 6th most common cancer in the United States. Metoprolol xl dose Clonidine for ptsd Cheap generic viagra co uk french index Where to buy generic viagra yahoo These highlights do not include all the information needed to use ZOLOFT safely and effectively. See full prescribing information for ZOLOFT. ZOLOFT sertraline. Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft sertraline, frequency-based adverse effects, comprehensive interactions. Depression is common among older adults. It’s estimated that 7 million American adults over the age of 65 experience depression each year. These emotions usually only last a few hours or days. It’s when you feel down or upset for long periods of time, and when those feelings are very strong that these feelings are considered depression. Depression is a serious mental disorder that can interfere with your daily life. It can make it hard for you to carry out your daily activities and find pleasure in the activities you once enjoyed. In fact, it’s one of the most common mental disorders in the United States, according to the National Institute of Mental Health (NIH). According to a study by the Substance Abuse and Mental Health Services Administration (SAMHSA), 6 percent of American adults experienced at least one episode of depression each year of the decade beginning in 2005. Depression usually first occurs in early adulthood, but it’s also common among older adults, according to the NIH. Studies by the Centers for Disease Control and Prevention (CDC)estimate that 7 million American adults over the age of 65 experience depression each year. Anxiety disorders affect more than 18 percent of adults in the U. in a given year, according to the National Institute of Mental Health. These disorders cause symptoms that can make daily activities difficult. Medications are sometimes used to help alleviate some symptoms of an anxiety disorder. Some of these medications, such as benzodiazepines, may be addictive and are used only on a short-term basis. Other antianxiety medications can be used on a long-term basis without the risk of addiction. See your doctor to determine whether medication is appropriate to include in the management plan for your anxiety disorder. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are medications that alter the balance of chemical messengers in the brain. Zoloft for elderly Popular Antidepressants Not Always Best Choice for Seniors, Zoloft sertraline dosing, indications, interactions, adverse effects, and. Prednisone and cancerDoxycycline alternative Can Zoloft cause confusion in the elderly? Are there special concerns regarding Zoloft for seniors? These are questions you should ask yourself before. What You Need to Know About Zoloft and Seniors LoveToKnow. Depression and the Elderly Symptoms, Statistics.. Zoloft Oral Uses, Side Effects, Interactions, Pictures, Warnings - WebMD. Managing Insomnia and Anxiety In the Elderly Francisco Fernandez, M. D. Professor and Chair USF Health Department of Psychiatry Insomnia - Objectives Sep 1, 2009. Generalized anxiety disorder is one of the more common mental illnesses affecting older people. Medication may not be the best treatment. Results from several well designed trials show that sertraline 50-200 mg/day is effective in the treatment of major depressive disorder in elderly patients or.