It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine and bafilomycin Hydroxychloroquine and liver cirrhosis Define plaquenil May 13, 2009 The anti-malarial drugs Hydroxychloroquine HCQ is widely used to treat various rheumatic diseases mechanism of action of this drug is to increase the pH in acidic vesicles, inhibiting receptor mediated endocytosis that affects many cellular functions including antigen presentation, toll receptor signaling and post-transcriptional modification of proteins 2–4. OBJECTIVE The use of hydroxychloroquine HCQ in pregnancy remains controversial. The recent demonstration that HCQ passes across the placenta, with cord blood concentrations nearly identical to those found in maternal blood, emphasizes the need for careful evaluation of pregnancies in women receiving HCQ. Hydroxychloroquine in Lupus Pregnancy Megan E. B. Clowse,1 Laurence Magder,2 Frank Witter,3 and Michelle Petri3 Objective. Hydroxychloroquine HCQ is often needed to manage disease activity in systemic lupus erythematosus SLE during pregnancy. The purpose of this study was to examine lupus activity and pregnancy The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Pregnancy category hydroxychloroquine Plaquenil and Pregnancy rheumatoid, Safety of hydroxychloroquine in pregnant patients with connective. Chloroquine phosphate tablets ip 250 mgHydroxychloroquine retinal toxicity retina replacementBenadryl and plaquenil Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2 Drug Safety in Pregnant & Nursing Women. Hydroxychloroquine in Lupus Pregnancy. Hydroxychloroquine in lupus pregnancy - Clowse - 2006 - Arthritis &.. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. This sheet talks about whether exposure to hydroxychloroquine may increase the risk for birth defects over that background risk. Background The use of the hydroxychloroquineHCQ in pregnancy is controversial. The current practice of discontinuing these medications because of pregnancy makes little sense as the half-life of these medications is so long. Patients with autoimmune diseases, especially with systemic lupus erythematosus SLE have increased fetal wastage and one of the factors known to contribute to this. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.