Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Splitting hydroxychloroquine Chloroquine atovaquone How long does plaquenil stay in yoursystem Side effects of hydroxychloroquin The world’s largest association of eye physicians and surgeons, we advocate for patients and the public and set standards for ophthalmic education. The recommended dose was calculated based on the American Academy of Ophthalmology AAO 2016 guidelines recommendation of not more than 5 mg/kg/day actual body weight. Patients were also asked about unwanted symptoms they had reported to their doctor, gastrointestinal GI effects they had experienced and aspects affecting their adherence. Recommendations by the AAO to limit HCQ dosing to 6.5 mg/kg of ideal body weight have been 31 revised to 5 mg/kg of actual body weight 5. Some authors recommend 6.5 mg/kg of actual 32 body weight with a cap at 400 mg per day and further adjustments for renal insufficiency 10. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil guidelines aao 2016 Plaquenil Guidelines Point Out New Risks, New Presentation., Hydroxychloroquine usage in US patients, their experiences of. Methylene blue falciparum chloroquine sensitizeChloroquine and filipina clathrin mediated endocytosisAmoebic liver abscess treatment chloroquineAre there any withdrawal symptoms from plaquenilSide effect plaquenil rash The latest screening guidelines were published in 2016 by the American Academy of Ophthalmology Table 1. The most important risk factors are dosage and duration of use. Dosage greater than 5.0mg/kg over five years dramatically increases the risk of retinal toxicity, and high doses can be exceedingly dangerous. How to Succeed in Plaquenil Screenings. AMERICAN COLLEGE OF RHEUMATOLOGY. AAO Guidelines for Chloroquine Screening. The AAO revised the guidelines in 2016 to define excess doses of hydroxychloroquine as greater than 5.0 mg/kg of actual body weight Ophthalmology. 2016;186-94. Based on these new guidelines, the investigators found that 56% of 527 patients who were currently. Background/Purpose Hydroxychloroquine HCQ is a widely-used medication in many rheumatologic conditions. The most worrisome toxicity is irreversible damage to retinal pigment epithelium which can lead to blindness. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity1. According to these Impact of the revised American Academy of Ophthalmology guidelines regarding hydroxychloroquine screening on actual practice. Easterbrook M, et al. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy a report by the American Academy of Ophthalmology. 186-1394 2016 by the American Academy of.