Studies have shown that atovaquone and proguanil hydrochloride is safe and effective for prevention of falciparum malaria in lifelong residents of malaria-endemic countries, but little is known about non-immune travellers. In a double-blind equivalence trial, 1083 participants travelling to a malaria-endemic area were randomly assigned to two treatment groups: atovaquone-proguanil plus placebos for chloroquine and proguanil, or chloroquine, proguanil, and placebo for atovaquone-proguanil. Chloroquine proguanil dose Synthesis of chloroquine phosphate ppt Plaquenil rp Obgyn plaquenil lupus OverviewMedical usesAdverse effectsOverdoseResistance in malaria Jun 15, 2004 On the basis of observed trends, the proportion of subjects who took ⩾80% of prescribed doses was similar in the 2 treatment groups for the pretravel period 90% for atovaquone-proguanil recipients vs. 95% and 90% for chloroquine-proguanil recipients, respectively and during travel 98% vs. 99% and 100%. Compare Malarone vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Malarone rated 5.1/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Serum samples were tested for antibodies to a malaria circumsporozoite protein. Follow-up was by telephone 7 and 60 days after travel and at a clinic at 28 days. Chloroquine vs atovaquone CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria, Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria. Plaquenil standard doseChloroquine malaria drug This medication contains 2 medicines atovaquone and proguanil. It is used to prevent and treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Atovaquone-Proguanil Oral Uses, Side Effects, Interactions.. Malarone vs Plaquenil Comparison -. History of antimalarials Medicines for Malaria Venture. Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of the antimalarial medication. Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%. Chloroquine has side effects, but is the recommended drug for the nature of mosquito/nature of malaria in the DR. Malarone works for other malarias my friend who spent 2 months in Kenya took it. Rather like the flu shot which treats only certain strains and not all. Chloroquine can also be used to treat malaria after you get it. Kaki On the basis of observed trends, the proportion of subjects who took ⩾80% of prescribed doses was similar in the 2 treatment groups for the pretravel period 90% for atovaquone-proguanil recipients vs. 95% and 90% for chloroquine-proguanil recipients, respectively and during travel 98% vs. 99% and 100%.