Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and lung cancer Smoking and plaquenil HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. The lowest GoodRx price for the most common version of hydroxychloroquine is around $18.60, 90% off the average retail price of $196.17. SIDE EFFECTS Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine loss of appetite Plaquenil side effect, loss of appetite, HYDROXYCHLOROQUINE - ORAL Plaquenil side effects. Hydroxychloroquine retinopathy side effects Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. Plaquenil and loss of appetite - Lupus - MedHelp. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine Sulfate Decreased Appetite Reports.. Hydroxychloroquine may not prevent malaria in all cases. If you experience fever or other symptoms of illness, seek immediate medical attention. Nausea, stomach cramps, loss of appetite. Loss of appetite, tiredness, weakness, or headache are uncommon side effects and typically go away over time. Rare complications The greatest concern people have when taking hydroxychloroquine is related to vision. Posted 3/10/2013 AM GMT -6 Since being diagnosed with Lupus and taking the normal meds, particularly Plaquenil and Prednisone over about 6 years, I gained about 45 pounds. Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok.