In general, it's important to mention this to your prescriber. Hydroxychloroquine (Plaquenil and generics) can itself cause fatigue in some users, it can interrupt sleep patterns (especially by causing more vivid dreams) which in turn makes one more tired. Plaquenil pronounciation Hydroxychloroquine warts Wiki hydroxychloroquine Hydroxychloroquine and bloating Either that or maybe I am developing FM as well.anyhow, the plaquenil has helped my joint pain but after 6 months I have more fatigue, muscle pain and overall discomfort than I did before. For the past month I haven't been able to hold my arms over my head for more than a few seconds due to the pain. Hi, Carole. When I started Plaquenil, my GI system was in an uproar. But it usually was anyway. I didn't realize, until I saw Dr. Wallace's book and found the stats, plus my rheumie telling me much the same, that many people with lupus something like 40% or more "present" with GI problems. Is extreme fatigue a side effect of Plaquenil - NRAS. Is extreme fatigue a side effect of Plaquenil. I've been on Plaquenil now for three months and its starting to help with the pain although I have diarrhoea every day but it's manageable. But I'm really struggling with fatigue now - worse than its ever been. This is especially true in those individuals with G6PD deficiency. The drug can also lower blood counts (red cell, white cells and others too) which in turn can cause fatigue. Plaquenil fatigue Hydroxychloroquine MedlinePlus Drug Information, Immune & Autoimmune - Lupus "Natural" alternative to Replacement for hydroxychloroquinePlaquenil usage and autismPlaquenil toxicity monitored with In other cases, the fatigue can be caused by another condition, such as anemia or depression. Fatigue can also be a side effect of medication. If fatigue hinders you, there are ways you can try to increase your energy with lupus. This article offers five key ways to cope with fatigue and boost your energy levels. Fighting Lupus Fatigue and Boosting Energy. Is extreme fatigue a side effect of Plaquenil - NRAS. Plaquenil for fatigue and pain DailyStrength. I started on the Plaquenil a little over a week ago. Not much in the way of side effects. Some minor stomach stuff but that could be normal and not related to the Plaquenil. I started at 200mg and increased to 400mg after a week. Andie213, my fatigue has been frustrating for me as well. Oct 23, 2005 Has anyone's doctor suggested Plaquenil for chronic fatigue syndrome? My rheumy has a couple of times. He says it could help with energy level because it is an immune enhancer. My mother took it for rheumatoid arthritis years ago and thinks it's worth a shot. My only concern is the. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long- term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.