I saw a GP about it (not my usual one) and they strongly suspect it is being caused by MTX but I have just spoken to the Rheumy nurse who thinks Hydroxy is the more likely suspect or it may be an autoimmune response so now I have to withhold all rheumy meds. It seems to improve when I am on steroids but only at higher doses. Thanks, Tamara I am on all sorts of meds including MTX and Hydroxy. How does hydroxychloroquine sulfate work for arthritis Plaquenil neuropathy Hydroxychloroquine and bruising Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Can plaquenil hydroxychloroquine cause a blistering rash on palms of hands. Is that a common side affect. I am also vomiting everyday. How long does it take for plaquenil hydroxychloroquine to work with rashes? Plaquenil hydroxychloroquine has brought ANA, SED, C-Reactive down. I function-barely. Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include I can't face the GP again, as I am sure I am one of the "heart-sink" patients! I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! Hydroxychloroquine causing rash where Ask the Expert Plaquenil and Sjögren’s, Plaquenil hydroxychloroquine 200mg is it causing itchy. Does hydroxychloroquine affect periods Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine - Wikipedia. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. I had an itchy rash due to methotrexate. They thought it was most likely to be caused by Cimzia, so stopped both drugs, restarted MTX and the rash came back. So I had to stop that and started on new medication after the rash had subsided. The doctor hasn't seen that before, so it's not always the cause. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks.