In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. What if i accidentally take 2 plaquenil Treatment of hydroxychloroquine retinopathy What helps nausea from plaquenil Using multivariate logistic regression, we found that HCQ-induced pigmentation was independently associated with previous treatment with oral anticoagulants and/or antiplatelet agents and with higher blood HCQ concentration. Conclusions and Relevance Hydroxychloroquine-induced pigmentation is not a rare adverse effect of HCQ. Our data support the hypothesis that HCQ-induced pigmentation is secondary to ecchymosis or bruising. Aug 18, 2011 Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus. Skin, the largest organ of the human body, is a mirror of your health. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Plaquenil associated hyperpigmentation Hydroxychloroquine-induced Hyperpigmentation of the Skin., Skin Discoloration and Plaquenil - Arthritis Information Ic hydroxychloroquine 200 mgPlaquenil tb riskPlaquenil ands ex drive FU has also been reported to cause hyperpigmentation overlying the vein into which it was infused. This has been labeled "serpentine supravenous hyperpigmentation" and may also be associated with alkylating agents, antibiotics, antimetabolites, proteasome inhibitors, and anti-mitotics. Drug-Induced Pigmentation Background, Pathophysiology, Etiology. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Health conditions that can cause hyperpigmentation. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti- inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals. Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Aug 14, 2013 A skin biopsy of the patient’s dyschromia confirmed the diagnosis of hydroxychloroquine-associated hyperpigmentation. Conclusion Hyperpigmentation of skin, mucosa, and nails can be observed in patients treated with antimalarials, including hydroxychloroquine.