Please review the following URL and make sure that it is spelled correctly. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil and esophagitis Chloroquine diphosphate intercalator dna Abnormal hydroxychloroquine visual fields One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. Medications and Sleep Some common RA medications may also contribute to sleeplessness. One is the steroid prednisone, which can cause insomnia, agitation or depression. Taking it earlier in the day is best, says Dr. Rosian. Another is hydroxychloroquine Plaquenil. It can sometimes causes people to get jumpy, nervous and twitchy. Fragmented Sleep Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil sleeplessness Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Rheumatoid Arthritis and Sleep Arthritis Foundation Plaquenil retinal toxicity Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil Side Effects Common, Severe, Long Term -. Types of Medication Known To Cause Insomnia and Nightmares Are.. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil and Insomnia - from FDA reports Summary Insomnia is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. RLS may be associated with another, more common condition called periodic limb movement of sleep, which causes your legs to twitch and kick, possibly throughout the night, while you sleep. People typically describe RLS symptoms as abnormal, unpleasant sensations in their legs or feet. They usually happen on both sides of the body.