Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine dreams Plaquenil rash Generally, the side effects can be noticeable fairly soon after first taking the medication although not always; prednisolone is an example where the side effects can take a while to manifest themselves so if you've been taking plaquenil for a while without developing lichen planus, it's possible that you may not have the problem. Sep 19, 2010 I've been taking plaquenil for about 5 years now. I gain weight with it. I take daypro for my RA also. I think the daypro helps with the swelling, as far as the pain goes there is always pain, in time you just learn to ignor and grow a higher tolerance for pain. I've had RA for 18 years. I'm 40 now. I was 22 when I found out I had RA. On plaquenil always made me feel very bad. hate it. before my diagnosis I was tired,aneamic,stiff etc since the plaquenil I jus flare all the time. it was so bad I just came off it for several months. got so ill they wanted me to go on chemo based drugs but I did not want that either. so reluctantly went back on the plaquenil. imo its made me worse. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Can plaquenil make ra worse Arthritis -- getting worse with plaquenil?, Does anyone else feel worse on Plaquenil? Chloroquine excretion Feb 19, 2020 What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. When starting hydroxychloroquine do symptoms feel. - LUPUS UK. Plaquenil vs Methotrexate rheumatoid. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. I have been on Plaquenil/Hydroxychloroquine for about 6 weeks now and I have not noticed any improvement, in fact my RA has actually gotten worse. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? May 25, 2010 I don't know if this is just the way RA is, or if it is a side effect of the medicine. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed.