I have been getting these horrible rashes and they are not related to sun exposure. I am starting to wonder if they are related to Plaquenil. Plaquenil 2 mg Plaquenil prednisone and methotrexate Hydroxychloroquine normal dose You are in a tough situation. If I understand your history correctly, you started having the alopecia despite being on the plaquenil 2 years ago. Now that you're off the plaquenil, there is more fatigue and joint aches. Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. I am interested to see if anyone here has gotten a rash from Plaquenil after being on it for several months. I have been getting these horrible rashes and they are not related to sun exposure. I am starting to wonder if they are related to Plaquenil. My doctor now wants me to start on Chloroquine instead of plaquenil. It seems that after being on a medication for years that has worked seems to loss it's affect or you may develop an allergy to that medication. I had to switch to Cybalta to treat my depression and admit that I was suffering from Fibromyalgia and that Cybalta would would help. I've always been one to go for the natural route and am starting to feel like I should just stop taking everything and see what happens - so frustrating. My doctor now wants me to start on Chloroquine instead of plaquenil. Allergy to plaquenil after being on it for years The Risk of Retinal Toxicity with Plaquenil, Plaqunil rash - Plaquenil risk of deathSide effects of long term use of hydroxychloroquine I have a sulfa allergy, and have taken Plaquenil for 4 years without any adverse effects. I can say, however, that I have not had any cross allergic reaction to other drugs sometimes associated with sulfa allergies. Plaquenil and Sulfa Allergies" Lupus Community - Support Group. Doc just put me on a med called Hydr. - HealthUnlocked. Allergy to Plaquenil - Lupus - Inspire. Been on Plaquenil for 30 years for rheumatoid arthritis. I don’t know if I have side effect from this drug as they are intermittent. Itching - weird times not consistent Eye watering - constant Headaches - hormonal, RA related Always had thin hair - never fell out No stomach issues ever Get eyes checked 1x a year. Mar 07, 2012 Hi looloo. I hope your able to respond to my question seeing that this discussion took place quit some time ago. Did you feel tingling and numbness when you stopped plaquenil? I am getting off the drug after being on it for four years and I am not experiencing nerve pain in my feet and legs. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use.