In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Hydroxychloroquine sulfate and sun exposure Plaquenil worse before better Flu shot and hydroxychloroquine Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known. Blistering, peeling, loosening of the skin; blurred vision or other vision changes; chest discomfort, pain, or tightness; cough or hoarseness; dark urine; decreased urination; defective color vision; diarrhea; difficulty breathing Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Plaquenil and Skin hyperpigmentation - a real-world study. Summary Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram. JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)A, Bluish-green pigmentation on the legs in a patient with systemic lupus erythematosus without lupus lesions at the time of the skin biopsy. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine and skin darkening Localized Argyria With Pseudo-ochronosis MDedge Dermatology, Hydroxychloroquine-Associated Hyperpigmentation. - PubMed Central PMC Plaquenil and rheumatoid nodulesPlaquenil generic vs name brandHydroxychloroquine 3d If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Common and Rare Side Effects for Plaquenil Oral. Will you have Skin hyperpigmentation with Plaquenil - eHealthMe. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. I have no idea if this is like what is happening to you, but when I first went on plaquenil I got some weird pigment changes on my forehead some darkening that has ended up being permanent. My rheumy said that plaquenil can make you even more sun sensitive, so it looks like some sun exposure along with the plaq caused my pigment changes. Hydroxychloroquine pigmentation can occur within 1 year after starting therapy 4, 12, 13, 17. The skin discoloration has no systemic adverse sequelae. After discontinuation of the drug, the hydroxychloroquine-associated pigmentation slowly fades. One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins.