Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil storage water or fat soluble Hydroxychloroquine tests Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hypoglycemia Plaquenil has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications see DRUG INTERACTIONS and ADVERSE REACTIONS. Patients treated with Plaquenil should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil cause disufl Plaquenil Side Effects on Your Eyes and Vision, Plaquenil - FDA prescribing information, side effects and uses Hydroxychloroquine libido Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis or HIV/AIDS; antidepressants or antipsychotic medicines; birth.