Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and muscle stiffness Plaquenil ocular side effects Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. Serious Side Effects of Plaquenil. Some patients will be able to go back to the same dose eventually. After one to three months, people with rheumatoid arthritis usually have a good response. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects back pain Will you have Back pain with Plaquenil - eHealthMe, Stopping plaquenil. DailyStrength Tramadol and plaquenilPlaquenil neuropathyPlaquenil alcohol interactionPlaquenil and leukemia Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Hydroxychloroquine Reviews Everyday Health. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil Side Effects - GoodRx. I had neuropathic pain a couple of months back, but my Dr. put me amlodipine for my Ryanauds, and after starting that, that pain has stopped. It was horrible too! I just got my prescription for Plaquenil and I have not started it yet. I am kind of nervous about it with the side effects. I will be interested in hearing what others have to say. Find information about common, infrequent and rare side effects of Plaquenil Oral. Side Effects. Drug information provided by IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. lower back or side pain noisy breathing painful or difficult urination red irritated eyes red skin lesions.