Plaquenil use with retinopathy

Discussion in 'Canadian Drug' started by Madzsar, 07-Mar-2020.

  1. Niazida XenForo Moderator

    Plaquenil use with retinopathy


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy. Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil use with retinopathy

    Plaquenil Toxicity - Symptoms, Treatment, Risk Factors., Retinal Physician - Hydroxychloroquine Maculopathy An.

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  6. Figure 6 This is a Kaplan Meier curve showing the cumulative risk of retinopathy over time, with different levels of hydroxychloroquine HCQ use. When use is between 4.0 and 5.0 mg/kg, the risk is very low within the first 5 to 10 years, but it increases markedly thereafter. Reproduced from Melles and Marmor, 2014 7

    • Hydroxychloroquine Plaquenil Toxicity and Recommendations..
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    Hydroxychloroquine is the most commonly used AM, specifically because it has a lower risk for retinal toxicity than chloroquine. This may be because CQ crosses the blood-retinal barrier and HCQ does not. There is no retinal damage associated with the use of quinacrine. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Postmarketing cases of lifethreatening and fatal cardiomyopathy have been reported with use of PLAQUENIL as well as with use of chloroquine. Patients may present with atrioventricular block, pulmonary hypertension, sick sinus syndrome or with cardiac complications.

     
  7. okk Moderator

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Side Effects of Voltarol Common and Rare Side Effects for Hydroxychloroquine Oral Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  8. GoodDesign New Member

    What Is Hydroxychloroquine Used For? Hydroxychloroquine is used for treating and preventing malaria. As this eMedTV page explains, it can also be used to treat lupus or rheumatoid arthritis. This article also lists common off-label hydroxychloroquine uses and explains how the drug works.

    Hydroxychloroquine Side-effects, uses, time to work
     
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