Metoprolol and cocaine

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    Metoprolol and cocaine


    The following is a hypothetical example of a classic exam question that one might come across as a medical student: A 50-year-old male presents to the emergency department with severe chest pain. His past medical history is significant for congestive heart failure and stent placement. His vitals are significant for a blood pressure of 220/110 and a heart rate of 170. All of the above are acceptable to use in the setting of cocaine-related chest pain If you said D, you would most likely receive full credit, for the classic teaching is that beta-blockers are contraindicated in the setting of chest pain related to cocaine use. On physical exam he appears to be profusely sweating, and his pupils are markedly dilated. Beta-blockers are also frequently withheld from patients with significant heart disease who happen to be active users of cocaine. Troponin I is within normal limits and EKG shows normal sinus rhythm. As medical students we learn not to use beta-blockers in such a setting on many occasions, from test questions like the one above, to mannequin simulations, to interactions with patients on the hospital wards. When prompted, the patient admits to snorting cocaine just a few hours prior to presentation. However, one should question the reasoning behind the practice of not giving beta-blockers to patients who use cocaine. Which of the following should NOT be used in the management of this patient’s symptoms? After all, if as clinicians we choose not to prescribe cocaine users a drug that has a significant mortality benefit in the setting of coronary artery disease [1,2], one might presume that there would be some good evidence to support this practice. Years ago I treated a university student who presented to the emergency department (ED) after drinking several cans of a popular caffeinated energy drink to “pull an all-nighter” during final exam week. He was tremulous, agitated, and pale, with sinus tachycardia ranging from 140 to 160 bpm and normal blood pressure (BP). The house officer (registrar) working with me that night proposed treating him with a benzodiazepine, but I pointed out he had an important exam to take in a few hours and had driven himself to the ED. Rather than snow him with benzos, I suggested metoprolol, a lipophilic beta-1 blocker with both peripheral and central nervous system effects. Her response to this was, “Oh no, you can’t do that – what about unopposed-alpha stimulation? ” I told them I had never experienced or heard of a case of this at our hospital in my 20 plus years of emergency medicine, but I had always been looking for it. ” It was at this point I realized the level of misinformation regarding this dogma had become so pervasive, that newly-minted physicians were applying it as an absolute contraindication to beta-blocker treatment for stimulants. ” She replied, “It’s where you give a beta-blocker and their BP immediately skyrockets.” I asked some other house officers nearby: “It’s when they get an arrhythmia after beta-blockers,” and, “They get chest pain and MI right after beta-blockers, but only with cocaine.” “It puts methamphetamine and cocaine patients at high-risk for aortic and coronary artery dissection.” I then asked, “Have you ever seen it or heard of a case? It was kind of like the emergency medicine equivalent of a snipe hunt. Within minutes his tachycardia resolved, and he felt back to baseline. We watched him for another hour then discharged him.

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    He was successfully treated with metoprolol as the residents stood aghast at the possibility of the “unopposed alpha phenomenon”. The post. Ava-Metoprolol Metoprolol belongs to the class of medications called. cobicistat; cocaine; cyproterone; darifenacin; delavirdine; dextromethorphan; digoxin. Metoprolol is a beta-blocker that affects the heart and circulation blood flow through arteries and veins. Metoprolol is used to treat angina chest pain and hypertension high blood pressure. Metoprolol is also used to lower your risk of death or needing to be hospitalized for heart failure. Important Information

    Metoprolol belongs to the class of medications called beta-blockers. Metoprolol is used to treat high blood pressure and prevent the symptoms of certain types of angina (chest pain). It is also used to help reduce the risk of death right after a heart attack. Metoprolol is also taken by people who have had a heart attack to reduce the risk of having another one. Metoprolol is often used in combination with other high blood pressure medications such as diuretics (water pills) when the use of one medication by itself is not enough to control blood pressure. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. What are the potential interactions and history between cocaine and beta blockers? The following provides information about what beta blockers are, and the relationship between cocaine and beta blockers, including interactions and history. Before looking at the interactions and history of cocaine and beta blockers, what are beta blockers? Beta blockers are also referred to as beta-adrenergic blocking agents, and they can treat many different conditions ranging from migraines to high blood pressure. Beta-blockers stop the impact of epinephrine, which is a hormone more commonly known as adrenaline, and in doing so, they reduce blood pressure. When you take a beta blocker, it slows your heartbeat and makes it less forceful, which ultimately lowers blood pressure. When you take beta blockers, it also helps improve blood flow by opening vessels.

    Metoprolol and cocaine

    Beta Blockers for Cocaine and other Stimulant Toxicity, Ava-Metoprolol - Uses, Side Effects, Interactions -

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  3. Jan 11, 2019. Cocaine, purported to be the most potent stimulant of natural origin, is extracted from the leaves of the coca plant Erythroxylum coca, which is.

    • Cocaine Acute intoxication - UpToDate.
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    Should Beta-Blockers Be Used In The Setting Of Cocaine-Related Chest Pain? February 5, 2014. Cardiology Clinical Questions. By Matthew A. Haber. Metoprolol in acute myocardial infarction MIAMI. A randomised placebo-controlled international trial. The MIAMI Trial Research Group. Eur Heart J. 1985;63199-226. Of beta adrenergic receptor antagonists in patients with cocaine- associated myocardial. tion from a cocaine metabolite, with or without a metoprolol interaction. Administration in patients with cocaine associated chest pain and myocardial. metoprolol from 4.9% to 4.3%.9 These trials form the basis of the. ACC/AHA.

     
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    20, 2004-- Among the top 25 pharmacy sites with the highest percentage of users age 55 and older, 12 are foreign based, usually Canadian Pharmacies and Mexican Pharmacies U. seniors are fighting an increasingly difficult battle in their quest for affordable prescription drugs, and new Hitwise data indicate their search is spreading to neighboring countries via the Web. According to Hitwise, the world's leading online competitive Intelligence service, the foreign sites with the highest percentage of their U. visitors stemming from this older demographic are Canadian based: Canada Drugs ( at 53 percent; Med Center Store ( at 44 percent; and Doctor Solve ( at 42 percent. 11, 2004)"The latest online data bolster reports about the growing demand among seniors for lower drug prices," said Bill Tancer, vice president of research, Hitwise. "We've been hearing about seniors obtaining prescriptions via foreign mail-order, as well actually traveling thousands of miles to Canada or Mexico to purchase them. While there is growing controversy around this trend, the latest Hitwise data show that the Internet is increasingly augmenting these more conventional methods."While seniors are heavily driven to foreign sites, at 37 percent they also are the dominant demographic to visit the entire pharmacy category. The 55 age bracket is more than twice as likely as all others to visit pharmacy sites. Five of those sixteen include: Canada Pharmacy ( Mexican Pharmacies Online ( My Rx For Less ( Canada Drugs ( and Rx North ( This helps explain why sixteen of the 50 most popular pharmacy sites among all U. Approved canadian online pharmacies 98 mg CanadaPharmacyOnline - Certified Canadian Pharmacies Empire casino yonkers table games - Page 131 - ZCore Network
     
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