This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Chloroquine tablet prescription Chloroquine bioavailability Plaquenil cost for generic For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight. Acute chloroquine poisoning is often fatal; the lethal dose may be as low as 50 mg chloroquine base/kg. Nausea, vomiting and drowsiness, which occur rapidly, are followed by slurring of speech, agitation, visual impairment, breathlessness due to pulmonary oedema, cardiac dysrhythmias, convulsions and coma. In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. In this study, the terminal half-life of chloroquine was 3.1 hr after a single 250 mg oral dose, 42.9 hr after a single 500 mg oral dose. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine lethal dose Chloroquine Oral Route Proper Use - Mayo Clinic, WHO Model Prescribing Information Drugs Used in Parasitic. Metabolic fate of chloroquine The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. However, nontoxic cases have been reported up to 39 mg/l, suggesting individual tolerance to this agent may be more variable than previously recognised. Chloroquine - Wikipedia. Chloroquine C18H26ClN3 - PubChem. Chloroquine improves survival and hematopoietic recovery.. Chloroquine was administered to the mice in the first group as 20 mg/kg b.w. once a day for four consecutive days. Quinine at a dose of 20 mg/kg b.w. was given to the mice in the second group for the first day and 10 mg/kg b.w. for the second to fourth day. Large chloroquine overdoses are almost inevitably fatal. We describe the presentation and management of a patient with such an overdose who survived, due to general supportive care and new specific treatment. What Is the Chloroquine Dosage for Preventing Malaria? The usual dosage for malaria prevention in adults is 500 mg once a week. The chloroquine dose in children is based on the child's weight. Children either receive about 8.3 mg per kg of body weight about 3.8 mg per pound of body weight or the adult dose, whichever is less.