The most common side effect associated with its use is retinal toxicity, which may be irreversible. Therefore, it is pertinent to know the findings, risk factors, and screening tests necessary to prevent retinal damage. Mechanism of resistance to chloroquine Hydroxychloroquine drug classification Plaquenil 200 mg canada Among the clinical imaging modalities, optical coherence tomography OCT is one of the most important because it provides sensitive detection of outer retinal changes caused by the drug. Accordingly, the guidelines suggest OCT as a key screening test for structural assessment of the drug's toxicity. 5 Objectives To compare different screening procedures for hydroxychloroquine sulfate Plaquenil toxicity at different stages of damage. Methods Ten patients were studied using 10-2 automated fields, multifocal electroretinography, spectral domain optical coherence tomography SD-OCT, and fundus autofluorescence. My Take on New Ocular Screening Guidelines for Plaquenil By Sergio Schwartzman, MD 12 October 2016 A recent article published by the American Academy of Ophthalmology AAO presented new recommendations for screening of patients being managed with hydroxychloroquine HCQ. During the first five years of use, the rate of toxicity was found to be 0.7%, rising significantly to more than 1% after five to seven years of use. The prevalence of retinal toxicity has varied among different studies. Oct plaquenil screening New Plaquenil Guidelines -, Comparison of Screening Procedures in Hydroxychloroquine Toxicity. Hydroxychloroquine sulfate and prednisone togetherHydroxychloroquine 200 mg pricesSide effect plaquenil eyesDmards for rheumatoid arthritis instead of plaquenil Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Multimodal Imaging in Plaquenil Toxicity. My Take on New Ocular Screening Guidelines for Plaquenil.. Expanded spectral domain-OCT findings in the early detection.. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Earlier screening is recommended for patients with any of the previously mentioned risk factors. Annual screening examinations include biomicroscopy, automated 10-2 visual field and spectral domain optical coherence tomography SD-OCT with optional fundus autofluorescence FAF and/or multifocal electroretinogram mfERG as needed. Mar 01, 2011 New Screening Guidelines for Hydroxychloroquine Toxicity Experts explain their role in clinical practice. Stephen G. Schwartz, MD, MBA • William F. Mieler, MD. Hydroxychloroquine Plaquenil, Sanofi-Aventis remains widely used in the treatment of various rheumatologic disorders.