Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Diamondback chloroquine phosphate Aralen patient teaching Hydroxychloroquine sulfate davis pdf Plaquenil weight The Diopsys® mfERG vision test is a painless, safe, non-invasive way for your eye care provider to objectively measure the function of your retina – the light-sensitive layer at the back of your eye. When light from an image enters your eye, it is turned into electrical energy by cells in the retina. MfERG changes correlate with both structural SD-OCT and functional HVF 10-2 findings in detecting HCQ retinopathy 89, 90. Maturi et al. noted that mfERG changes were associated with a cumulative dose of 500 g and 5 years use and could be classified into four patterns paracentral loss, foveal loss, peripheral loss and generalized loss. Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity A review Review of mfERG ring ratios in Plaquenil toxicity. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Mferg plaquenil Advanced Multifocal ERG mfERG Diopsys, Hydroxychloroquine-related retinal toxicity Rheumatology. Chloroquine mode of mechanism action What is Plaquenil? Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Using multifocal ERG ring ratios to detect and follow.. PowerPoint. Update on Plaquenil Testing. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says.