In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine side effects anxiety Chloroquine and adverse drug events Spell plaquenil Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. AT A GLANCE • Long-term use of hydroxychloroquine sulfate may result in parafoveal retinal toxicity. • No single imaging platform can confirm the presence of hydroxychloroquine toxicity. • Microperimetry and adaptive optics are undergoing studies to confirm their usefulness in. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Hydroxychloroquine poisoning Chloroquine and Hydroxychloroquine Toxicity Practice., PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION What is chloroquine given for Sep 15, 2014 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions, with less toxic effects than chloroquine. Retinal toxicity associated with chronic exposure to.. Retina Today - Imaging in Hydroxychloroquine Toxicity April.. Accidental hydroxychloroquine overdose resulting in.. Call a poison control center at once and then seek emergency medical attention if you think you have used too much of this medicine. An overdose of hydroxychloroquine can be fatal, especially in children. Take hydroxychloroquine for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions, with less toxic effects than chloroquine. Hydroxychloroquine overdoses are rare, but very serious. Life-threatening symptoms may occur within 30 minutes with very rapid progression to death within a few hours. The symptoms are similar to chloroquine overdoses.