Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine side effects skin rash Plaquenil and parasites Retinal toxicity with degeneration of the RPE and neurosensory retina as a result of long-term daily use of chloroquine has been well described. 29–35 However, most cases of retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 36 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 37 One study showed a 19% incidence of chloroquine retinopathy in. My understanding is that the rheumatologist thinks that plaquenil is synergistic with mycophenolate and the 2 have a better chance of halting the progression of the neuropathy, and the other current and possible impacts of Sjogren’s better than mycophenolate alone. Neuropathy dominates my symptom set, with fatigue and oral dryness right up there. Symptoms. Signs and symptoms of autonomic neuropathy depend on the nerves affected. They might include Dizziness and fainting when standing, caused by a sudden drop in blood pressure.; Urinary problems, such as difficulty starting urination, incontinence, difficulty sensing a full bladder and inability to completely empty the bladder, which can lead to urinary tract infections. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine and neuropathy Toxic Optic Neuropathy - EyeWiki, Mycophenolate mofetil with Plaquenil Mayo Clinic Connect Ibuprofen with plaquenilChloroquine bafilomycin a1 conventional autophagy Four patients were observed who developed similar episodes of peripheral neuropathy following prolonged treatment with chloroquine phosphate. This previously unreported toxic reaction consisted of bilateral loss of knee and ankle reflexes and weakness of the quadriceps muscles. Gradual return to normal followed withdrawal of the chloroquine. Peripheral Neuropathy Following Chloroquine Therapy. Autonomic neuropathy - Symptoms and causes - Mayo Clinic. Hydroxychloroquine neuromyotoxicity.. Hydroxychloroquine and colchicine neuromuscular toxicity is well documented. The largest literature review on colchicine myopathy was conducted by Wilbur and Makowsky in 2004 where a database search found 75 cases. Most patients presented with proximal muscle weakness. Diabetes and alcoholism are the most common etiologies of peripheral neuropathy in adults living in developed countries. The primary worldwide cause of treatable neuropathy is leprosy.1 Neuropathies associated with human immunodeficiency virus HIV infection account for an increasing number of cases. Did your muscle pain come before, after or with the neuropathy? Did the Plaquenil help with the muscle joint part of your problem? Where was your neuropathy and what are you taking now if anything? When I took the Plaquenil I had RA antibodies and it was muscle / joint related. Thanks for responding.