Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine sulphate Hydroxychloroquine 200 Hydroxychloroquine with tylenol I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I understand these may go away. Is there anything I can. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. I am 99% sure that the Plaquenil has not caused your fatigue. If anything, it’s Lupus OR psychosomatic. Plaquenil is a slow-acting drug which is why you take it long term. It honestly takes on average 1 to 3 months to work and be built up in your system, which is why you typically have a 3-6 month review after being prescribed it. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause extreme fatigue Plaquenil and Depression/Anxiety - Symptoms and Medical., Stopping plaquenil. DailyStrength Hydroxychloroquine side effect uworldPlaquenil abbreviation Chronic fatigue is a common RA symptom. Discover six ways you can better manage fatigue and find more energy to deal with rheumatoid arthritis. Chronic Fatigue From RA 6 Ways to Fight Back Everyday Health. Extreme fatigue on Plaquenil? lupus. Sjögrens Fatigue – an Autoimmune Conundrum! SjögrensLife. My rheumatologist just started me on plaquenil a couple of weeks ago. She said a half-dose - 200 mg because I'm skinny. My fatigue is out of control and ruining my life. I can barely hold on to my job and right after work, I fall asleep, like at 6 PM, then struggle with insomnia all night. Always feel exhausted. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. What is Plaquenil and what are its benefits for Sjögren’s patients? Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s.