In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine sulfate uses O hydroxychloroquine The optical coherence tomography angiography findings showed that the parafoveal deep temporal and deep hemi-inferior vascular plexus density was reduced in patients taking hydroxychloroquine for more than 5 years despite having normal perimetry. The Risk of Retinal Toxicity with Plaquenil. FA imaging, and optical coherence tomography. Recent findings suggest that Plaquenil toxicity can develop among patients that are taking the drug at a daily dose lower than the suggested “safe” dose and/or have been on Plaquenil for shorter than five years. Unfortunately, cessation of. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Oct findings in plaquenil toxicity How to Succeed in Plaquenil Screenings, The Risk of Retinal Toxicity with Plaquenil Seroquel and plaquenil interactionsCan you take plaquenil with flagylSarah ballantyne plaquenil In obvious toxicity, the nasal inner subfield showed more thinning than the temporal inner subfield at 12 months after drug cessation p = 0.018, 95 % CI −1 to −8 μm. Conclusions Once HCQ retinopathy is diagnosed and the medication is discontinued, structural retinal changes commonly occur. Expanded spectral domain-OCT findings in the early.. My Take on New Ocular Screening Guidelines for Plaquenil.. Hydroxychloroquine toxicity - EyeWiki. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Researchers recently reported on early optical coherence tomography OCT abnormalities due to HCQ toxicity that may develop through normal visual field VF testing. They found that patients with high-risk HCQ exposure and normal VF testing may develop subtle but characteristic OCT abnormalities. In Hydroxychloroquine Toxicity Michael F. Marmor, MD Objectives. optical coherence tomography. Patients with early and moderate toxicity had normal examination findings, whereas those with severe toxicity showed bull’s-eye retinal pigment epithelium atrophy.