It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Should i take hydroxychloroquine if i have high liver enzymes Plaquenil remission Any vision changes Plaquenil can cause severe and permanent eye damage Easy bruising or bleeding ; Frequent or severe infections ; Signs of heart problems, such as swelling of the ankles, shortness of breath, or an irregular heart rhythm arrhythmia Signs of an allergic reaction, such as Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Plaquenil, systemic lupus erythematosus, bruising, skin I have been taking the drug for almost two year for Sjogrens syndrome/lupus and recently I have noticed unexplainable brusing on my back and thighs For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and easy bruising Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis., Plaquenil Hydroxychloroquine - Side Effects, Dosage. Does plaquenil reduce rheumatoid arthritisLysosomal degradation inhibitor chloroquine Why Does Lupus Lead to Easy Bruising? Understanding Lupus Bruising. A purple butterfly may be the universal sign for lupus, but sometimes black and blue seems to be a more accurate color for the disease. Lupus appears to give me a visible beating at times, with multiple bruises popping up all around my body for no apparent reason or injury. Why Does Lupus Lead to Easy Bruising? – Lupus My Invisible.. Has anyone taking Plaquenil ever experienced bruising.. Plaquenil vs. Humira Prescription Treatment for Rheumatoid.. Unusual bleeding or bruising unusual facial expressions unusual tiredness or weakness yellow eyes or skin Symptoms of overdose. Drowsiness dry mouth increased thirst loss of appetite mood changes no pulse or blood pressure numbness or tingling in the hands, feet, or lips unconsciousness Unexplained bruising. deleted_user 11/09/2011. i've started to get really tender shins and bruising for no reason on my legs. I've seen my gp and they are miffed and have done some blood tests. I have alot of fatigue and my legs feel heavy, im on plaquenil and nifidipine for raynauds. has anyone else had this? 10. 0. Leave A Reply. Low blood counts can cause this so it may be something you need to bring to your doc. I'm not sure if Plaquenil lowers blood counts or not. I know since I'm on Methotrexate I have to keep an eye on this because it can lower my blood counts. My doc said that bruising commonly happens when you are on immunosuppressants.