These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color. Hydroxychloroquine for leg cramps Plaquenil sore throat Low-dose hydroxychloroquine is generally as effective as phlebotomy for treatment of PCT, but longer studies are needed to compare relapse rates. Singal AK, Kormos-Hallberg C, Lee C, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda. Porphyria cutanea tarda PCT is an iron-related disorder that results from reduced activity of hepatic uroporphyrinogen decarboxylase. Treatment options include phlebotomy or low doses of hydroxychloroquine. Phlebotomy is expensive, inconvenient, and can increase risk for anemia or syncope. Treatment of porphyria cutanea tarda can include Regular blood removal phlebotomies to reduce the amount of iron in the liver Low doses of the antimalarial drug chloroquine or hydroxychloroquine Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cells—red blood cells, white blood cells, and platelets. The body makes heme mainly in the bone marrow and liver. Low-dose hydroxychloroquine in treatment of porphyria Porphyria Cutanea Tarda PCT - American Porphyria Foundation, Is Hydroxychloroquine As Effective As Phlebotomy for Porphyria Cutanea. Chloroquine online pharmacy Has been used in treatment of porphyria cutanea tarda†. 114 116 117 See Patients with Psoriasis or Porphyria under Cautions. Has been effective in some cases when used in the treatment of polymorphous light eruptions†. Hydroxychloroquine Sulfate Dosage and Administration Administration Oral Administration. Administer orally. 109 Hydroxychloroquine Sulfate Monograph for Professionals.. How are acute porphyria and porphyria cutanea tarda treated?. Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda.. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment of Patients With Porphyria Cutanea Tarda. with on remis- sion by treatment with low dose hydroxychloroquine or. There were no significant side effects of either treatment. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified. High-dose hydroxychloroquine treatment of porphyria cutanea tarda. Petersen CS1, Thomsen K. Author information 1Department of Dermatology, Rigshospitalet, University Hospital, Copenhagen, Denmark. BACKGROUND High-dose hydroxychloroquine is rarely used in the treatment of porphyria cutanea tarda PCT.