Valtrex pdf

By: abeletsky Date of post: 02-Feb-2019
Information für den Anwender <b>Valtrex</b> 500 mg - GSK Kompendium

Information für den Anwender Valtrex 500 mg - GSK Kompendium

Valaciclovir ist ein Analogon der Nukleinbase Guanin. Es wird als Virostatikum bei Erkrankungen mit dem Varizella-Zoster-Virus (beispielsweise bei schwer verlaufendem oder generalisiertem Herpes Zoster) und mit Herpes-simplex-Viren eingesetzt. Valaciclovir ist ein sogenanntes Prodrug von Aciclovir und wird im Körper in dieses umgewandelt. Vorteile von Valaciclovir sind eine schnellere Resorption aus dem Darm und eine höhere Bioverfügbarkeit (etwa 55 % im Vergleich zu 10 %). Wirkungen und Nebenwirkungen entsprechen denen von Aciclovir. Als Arzneistoff wird ausschließlich das (S)-Enantiomer eingesetzt. Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism.

PRESCRIBING INFORMATION <b>VALTREX</b>

PRESCRIBING INFORMATION VALTREX

If your institution subscribes to this resource, and you don't have a My Access Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Corneas were inoculated with HSV-1, and latent infection was allowed to establish. Starting on postinoculation (PI) day 28, tear swabs were collected once daily for 6 consecutive days before treatment. The rabbits were placed in five balanced groups: group 1 had no treatment, group 2 received placebo, group 3 received 7 mg/kg VCV, group 4 received 70 mg/kg, and group 5 received 140 mg/kg. The treatment was administered by oral gavage twice daily, starting on PI day 36 and continuing for 14 days. The ocular swabs were collected beginning on PI day 40 and continuing for 10 days. The mean copy number of HSV-1 DNA before treatment was 370 ± 70, 569 ± 273, 368 ± 86, 408 ± 108, and 396 ± 91, and the mean HSV-1 DNA copy number after treatment was 232 ± 183, 564 ± 186, 518 ± 122, 67 ± 63, and 13 ± 7 in groups 1 to 5, respectively. The 70- and 140-mg/kg doses of VCV significantly reduced the HSV-1 DNA copy number, compared with that of the other three groups. A daily dose of 500 mg (∼7 mg/kg) VCV in healthy human volunteers did not suppress HSV-1 DNA shedding in tears and saliva.

<i>Valtrex</i> Uses, Dosage & Side Effects -
Valtrex Uses, Dosage & Side Effects -

Valtrex valacyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. Valtrex is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles herpes zoster in adults. Valtrex is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least. Senen siehe Abschnitt 4.4. Valtrex ist angezeigt zur Behandlung von. Herpes zoster bei Erwachsenen mit leichter oder mäßiger Immunsuppression siehe Ab-.

Valtrex pdf
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