Affecting 5-8% of women of reproductive age, recurrent thrush (defined as four or more episodes in 12 months) can affect quality of life, causing symptoms such as itching and soreness, painful sexual intercourse, discomfort when urinating, and abnormal discharge. It can be associated with frequent use of antibiotics, use of the oral contraceptive pill, immunocompromised states and hyperglycaemia. Professor Danielle Mazza and Alexia Matheson from the Department of General Practice at Monash University conducted a review of the current guidelines, in order to develop a summary of recommendations to assist in the management of women with this condition. They found the regimen suggested by most guidelines (fluconazole weekly for six months) is not particularly effective – only 42.9% of patients are disease free after 12 months. Some guidelines stated that results were comparable between fluconazole, clotrimazole and ketoconazole. Another offered boric acid inserts as an appropriate maintenance alternative, with rates of relapse up to 54.5% after six months. An alternative regimen put forward by one of the guidelines cites a 77% cure rate after 12 months, however this involved a year-long process of gradually weaning down oral fluconazole to provide remission. Thrush is a yeast infection caused by a fungus called Candida albicans. Both men and women can get thrush, though it is more often associated with women. In men, it usually affects the head of the penis – causing irritation, discharge and redness. Read more about the symptoms of thrush It can also affect the skin, known as candidal skin infection, and the inside of the mouth, known as oral thrush. If you suspect thrush for the first time, it's best to see a doctor for a diagnosis. This is because the symptoms can be similar to those of a sexually transmitted infection (STI). If you've had thrush before and you recognise the symptoms, you can treat it yourself with over-the-counter medication. You should also visit your GP if you have a weakened immune system and you have thrush. This is because there is a risk that a thrush infection could progress to a more serious case of invasive candidiasis.
Fluconazole 150mg capsules are also available without a brand name, ie as the generic medicine. Vaginal thrush is the common term for infections of the vagina with Candida species of fungi, in particular Candida albicans. This infection causes inflammation and discharge from the vagina. In men it causes soreness and redness of the penis, tightness of the foreskin, or a white, odourless discharge from the penis. Fluconazole kills the Candida fungi causing the thrush infection by making holes appear in their cell membranes. This allows essential constituents of the fungal cells to out, which kills the fungi and clears up the infection. Medicines and their possible side effects can affect individual people in different ways. Fluconazole is a type of medicine called a triazole antifungal. It kills fungi and yeasts by interfering with their cell membranes. Fluconazole works by stopping fungi and yeasts from producing a substance called ergosterol, which is an essential component of their cell membranes. Fluconazole causes holes to appear in the cell membranes, which allows essential constituents of the fungal or yeast cells to leak out. This kills the fungi or yeast, which either clears up the infection or prevents it from developing. Fluconazole is used to treat and prevent a number of different types of fungal and yeast infections, particularly those caused by Candida or Cryptococcus species of fungi. Fluconazole can be taken by mouth (as capsules or suspension) or may be administered via a drip into a vein (intravenous infusion) depending on the type and severity of the infection. The length of treatment needed depends on the type and severity of the infection.
Fluconazole is used to prevent and treat candidiasis. This condition is caused by infection with one of the many types of the fungus Candida. Examples of candidiasis include vaginal yeast. Single dose of Diflucan fluconazole is as safe and effective as taking Diflucan once daily for 14 days in curing oral candidiasis thrush