The study - conducted in nonhuman primates with brain structures and functions similar to those of humans - found that the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI) marketed as Zoloft, significantly increased the volume of one brain region in depressed subjects but decreased the volume of two brain areas in non-depressed subjects. "These observations are important for human health because Zoloft is widely prescribed for a number of disorders other than depression," said Carol A. D., professor of pathology-comparative medicine at Wake Forest Baptist and lead author of the study, published in the current online issue of the journal Neuropharmacology. In the study, 41 middle-aged female monkeys were fed a diet formulated to replicate that consumed by many Americans for 18 months, during which time depressive behavior in the animals was recorded. Female monkeys were chosen for this study because depression is nearly twice as common in women as men and the use of antidepressants is most common in women ages 40 to 59. After the 18-month pre-study phase, the monkeys were divided into two groups balanced for body weight, body mass index and depressive behavior. For the next 18 months, 21 monkeys received sertraline in daily doses comparable to those taken by humans while a group of 20 received a placebo. This treatment regimen is analogous to a human taking an antidepressant for approximately five years. If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access. By activating your account, you will create a login and password.
If you are considering taking an antidepressant, you may be concerned about how long you’ll need to stay on it. Even if you feel that it will help treat your depression, you may not like taking any medicine if you can help it. You may wonder about side effects or long-term effects of taking a drug that alters brain chemistry. If you’re already taking a medication for depression, you might be wondering about when to stop. If your mood and outlook on life have gotten brighter, do you really need to continue taking an antidepressant? In general, doctors recommend that people stay on an antidepressant at least one year to experience the full benefits. Beyond that, when -- and whether -- you should to go off depression medication is a personal choice that requires serious thought. Sertraline(Zoloft) by leading to serotonin accumulation in the synaptic clefts. It leads to increased neuronal activity and subsequent improvement in mood. SSRIs are selective and only work on serotonin receptors. They produce mood elevation and brain stimulatory effects. SSRI drugs like Sertraline are likely to produce many adverse side effects, so Zoloft initial side effects should always be kept in mind. Data from premarketing assessment shows that taking the drug may elicit several troublesome side effects of Zoloft. The study by Joel Kauffman from the University of Sciences in Philadelphia found that adverse effects may occur in up to 75% of individuals treated with SSRIs such as Sertraline.
ZOLOFT® sertraline hydrochloride is a selective serotonin reuptake inhibitor SSRI. The effectiveness of ZOLOFT in long-term use, that is, for more than 3. Apr 1, 2016. Thus, this is an ideal model in which to study the effects of long term SSRI. Sertraline HCl Zoloft® was introduced gradually over a 4 week.