Disruptive agitated behaviors frequently occur in Alzheimer's disease (AD), particularly among nursing home residents. These problem behaviors frequently precipitate nursing home placement and continue to cause patient distress and interfere with necessary care in the nursing home setting. Limited clinical trial data available suggest only modest efficacy and substantial adverse effects for antipsychotic and other psychotropic drugs prescribed for these problems. New approaches to pharmacologic treatment of these problem behaviors would be beneficial. Recent studies suggest increased behavioral sensitivity to central nervous system (CNS) noradrenergic stimulation in AD, and increased CNS noradrenergic outflow in the advanced stages of AD. These CNS noradrenergic characteristics may contribute to the expression of disruptive agitated behaviors in AD. Propranolol is a beta-adrenergic antagonist drug that decreases responsiveness to CNS noradrenergic stimulation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Gesell developmental schedules (GDS) were used to evaluate neurodevelopment outcomes in the two groups. The scores of each GDS domain were compared between the two groups. There were no significant differences in developmental quotient (DQ) values for any of the five domains between the patients and healthy controls Infantile hemangioma (IH) is the most common benign tumor in children. Most IHs are small, do not cause any complications, and involute naturally without treatment. However, approximately 10–15% of IHs can lead to compromised function and permanent disfigurement or are life-threatening. In certain cases, timely intervention is crucial for preventing potential sequelae [1, 2].
Jan 27, 2018. This is an open-access article distributed under the terms of the Creative Commons. Conclusion Propranolol has a long history of safe and. Feb 17, 2017. Expert advice about taking propranolol for anxiety, migraine, overactive thyroid and more. Propranolol is often taken on a long-term basis.