Perhaps most well-known in the performance enhancing world and its not a steroid, Nolvadex was originally developed with anything but performance enhancement in mind. Tamoxifen Citrate was originally brought to the market place by Imperial Chemical Industries (ICI) and introduced to the world as a suitable Morning After pill but in the end this would prove to be far from its positive purpose. Shortly after its inception is was discovered Nolvadex provided a formidable opponent against breast cancer but as is common soon performance purposes were found too. This is not an uncommon phenomenon, not by a long shot; many performance enhancing drugs start out as anything but performance enhancing drugs but so many in the end find this to be their primary purpose. However, unlike many anabolic steroids that have been found to fit this same bill Nolvadex does not actually enhance performance to a great degree but rather allows the individual to enhance more thoroughly as we will see; in-fact, Nolvadex has proven to be one of the more irreplaceable items in the arsenal of most performance enhancers. Comprised of the active compound Tamoxifen Citrate but more well-known by its most common trade name Nolvadex and often referred to simply as Nolva Nolvadex belongs to a class of drugs known as Selective Estrogen Receptor Modulators (SERMs.) In many ways this compound is very similar to another famous SERM Clomiphene Citrate (Clomid) with Nolva being more powerful on a milligram for milligram basis. Nolvadex exists as an antagonist of the estrogen receptors thereby preventing estrogen from binding and binding in its place. Nolvadex (Tamoxifen) belongs to a category and class of drugs known as selective Estrogen receptor modulators (SERMs). Selective Estrogen receptor modulators belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as aromatase inhibitors (AIs), such as Aromasin (Exemestane) and Arimidex (Anastrozole). Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control. The misunderstanding that SERMs, such as Nolvadex and Clomid, serve to lower estrogen levels must first be addressed before delving into any further details. This is a persistent rumor among the anabolic steroid using community that has begun to erode as of late, but the rumor still persists. SERMs serve to block the action of Estrogen at the receptor sites in breast tissue by occupying the receptor sites in place of Estrogen so that Estrogen itself cannot exert its effects there through receptor site binding. Conversely, SERMs will also act as Estrogens at receptor sites at other cells in other areas of the body (the liver, for example in Nolvadex’s case).
Nolvadex is net als Clomid een middel dat wordt gebruikt als anti-oestrogeen en (door die anti-oestrogene werking) als Post Cycle Therapy (PCT). Het zorgt er als PCT voor dat de normale hormoonhuishouding na een anabolenkuur sneller wordt hersteld. Dit voorkomt onder andere tijdelijk lage testosteron niveau’s die de tijdens de kuur gewonnen spiermassa weer snel verloren kunnen laten gaan. In het artikel over Clomid ga ik uitgebreider in op de noodzaak van PCT’s voor gebruikers van Anabool Androgene Steroïden. Nolvadex is de bekendste merknaam voor producten gebaseerd op het eiwit Tamoxifen zoals Deca-Durabolin het bekendste merknaam is voor Nandrolon (met een decanoaat ester). Andere merknamen zijn Caditam, Mamofen, Neotam, Oncomox, Oncotam, Tamodex, Tamoxifen, Tevafen, Tomifen, Valodex, en Xifen. Ik zal in de rest van het artikel hoofdzakelijk de generieke naam Tamoxifen gebruiken en in mindere mate de merknaam Nolvadex. This oral anti-estrogen complements Proviron well in a support treatment during your steroid cycle. Unlike Proviron, which is an anti-aromatic, Nolvadex blocks estrogen from attaching to estrogen receptors (SERM). Nolvadex is often used during PCT (Post Cycle Therapy or recovery), combined with Clomid for example, to restart testosterone production in the testicles. In the late 1950s, pharmaceutical companies were actively researching a new class of anti-estrogen compounds in the hope of developing a morning after contraceptive pill. The endocrinologist Arthur L Walpole directed a research team at ICI Pharmaceuticals. It was here in 1966 that Dora Richardson, a member of the research team, synthesized Tamoxifen for the first time, also known as ICI-46, 474. Walpole and his colleagues filed a British patent covering the compound in 1962, but patent protections were repeatedly denied in the United States.
Nolvadex belongs to a class of medications known as selective estrogen receptor modulators, more commonly known as SERMs. These drugs help to block the effects of estrogen by binding to estrogen receptors. When the receptors are filled with the SERM, less estrogen can attach, which renders it relatively useless. SERMs do not block all the estrogen in your body, which is beneficial since the male body does need some estrogen in order to remain healthy. Nolvadex was originally developed to help treat breast cancer. Some forms of breast cancer grow far more quickly when they have access to free estrogen in the bloodstream. Rather, they wait until the very end of the cycle and use it as post-cycle therapy. They do this for two very important reasons: to prevent estrogenic side effects and to Anabolic steroids suppress the body’s ability to make testosterone in very short order. Nolvadex, Nolvaxyl, Tamoximed, Tamodex, Cytotam, Mamofen, Xifen, Tomifen, Tevafen, Oncotam, Neotam, Valodex, Oncomox, Caditam, Nolva. Blue round-shaped pills with compact and homogeneous structure. 1 pill contains: Active substance: Tamoxifen Citrate 20 mg An estrogen agonist/antagonist used by bodybuilders and athletes in post-cycle therapy. It has the ability to increase production of follicle stimulating hormone and luteinizing hormone among males. Headache, confusion, problems with vision, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless, unusual pain in the pelvic area, blurred vision, speech, or balance, chest pain, sudden cough, wheezing, rapid breathing, fast heart rate, pain, swelling, warmth, unusual bleeding, fever and chills. The drug also restores adequate balance in hormonal levels. Not recommended in case of hypersensitivity to the drug, leukopenia, thrombocytopenia, hyperlipidemia, hypercalcemia, cataracts, pregnancy and thrombophlebitis. Is used in medicine for the treatment of metastatic breast carcinoma, as well as cancer of the endometrium, kidney soft tissue sarcoma, anovulatory infertility, postpartum agalactiа, oligospermia, pituitary tumors. During treatment it is necessary to monitor the leukocytes, platelets, calcium levels and blood coagulation system indices. In some pre-menopausal women, administering the drug to treat breast cancer may suppress the menstruation process. It is usually stacked with Proviron for a stronger anti-estrogenic effect.
This oral anti-estrogen complements Proviron well during your steroid cycle. Unlike Proviron, Nolvadex blocks estrogen from attaching to estrogen receptors. Nolvadex would likely be beneficial in anabolic steroid using athletes and bodybuilders that do not wish for a decrease in Estrogen levels, but instead wish to.