Another reason for weight gain is the use of corticosteroids. Some gain less, while others put on as many as 25 pounds. It’s common for women who have chemotherapy to gain about 5 to 14 pounds over a year. Menopause also causes you to gain more body fat and lose lean muscle. These medications help with nausea and swelling, or to stop reactions to chemotherapy. Corticosteroids are hormones that can also cause an increase in fatty tissue. Women treated with steroids may also put on pounds, but the weight gain is usually seen only after weeks of continuous use. They can make you lose muscle mass in your arms and legs, and gain belly fat, too. Some research suggests that weight gain is also related to lack of exercise . When you get your cancer treatment, it’s common to feel stress and have some fatigue, nausea, or pain. I’ve complained on this blog multiple times that cancer treatment didn’t make me thin, it made me fat. The culprit, I always maintained, was Tamoxifen, a drug that blocked by my cells’ ability to take up estrogen. My theory, unproven, was that fat cells produce estrogen. So my body, reacting to the lack of estrogen created by the drug, made fat cells. I would share this theory with my docs, and some would say, “Well, maybe. Other patients complain of weight gain on Tamoxifen. Carbs are my friend; no way am I giving up good French bread to go paleo. I continued these habits during the five years I was on Tamoxifen, yet I steadily gained weight. But there’s no proof.” Others were more blunt, “Tamoxifen does not cause weight gain.” I’ve been active my whole life: an athlete during school days, and an amateur in adulthood. Now, I’m off Tamoxifen, doing the same things I’ve always done and the weight slowly is coming off.
Sep 11, 2017. Your weight might change when you get treated for breast cancer. taking tamoxifen have felt the drug was responsible for their weight gain. Tamoxifen and anti-depressant use. Some types of anti-depressants called selective serotonin reuptake inhibitors SSRIs can interfere with the metabolism of tamoxifen how tamoxifen works in the body. Whether these SSRIs may impact the effectiveness of tamoxifen is under study.