Most experts state that all patients with symptomatic heart failure who have evidence for, or a history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction, an agent to inhibit the renin-angiotensin-aldosterone (RAA) system (e.g., ACE inhibitor, angiotensin II receptor antagonist, angiotensin receptor-neprilysin inhibitor [ARNI]), a β-adrenergic blocking agent (β-blocker), and in selected patients, an aldosterone antagonist. For solution and drug compatibility information, see Compatibility under Stability. IV administration may be used in emergency clinical circumstances when a rapid onset of diuresis is desired, or in patients unable to take oral medication or those with impaired GI absorption; replace with oral therapy as soon as possible. If needed, repeat same dose 6–8 hours later or increase dose by 20- to 40-mg increments and give no sooner than 6–8 hours after last dose until desired diuretic response (including weight loss) is obtained. For management of fluid retention (e.g., edema) associated with heart failure, some experts recommend initiating furosemide at a low dosage (e.g., 20–40 mg once or twice daily) and increasing dosage (maximum 600 mg daily) until urine output increases and weight decreases, generally by 0.5–1 kg daily. The use of furosemide in the treatment of edema in infants and children. Observe carefully for manifestations of fluid and electrolyte depletion (e.g., dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, arrhythmia, nausea, vomiting). Montvale NJ: Medical Economics Company Inc; 1940-2. Renal calcification reported in severely premature infants treated with IV furosemide for edema due to PDA and hyaline membrane disease; concomitant chlorothiazide therapy may decrease hypercalciuria and dissolve some calculi. Lasix (furosemide) injection, oral solution, and tablets prescribing information (dated 1994 Oct). Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide is pharmacodynamically characterized by the following: 1) Administered intramuscularly, it begins to act in about 30 minutes, and diuretic response is produced. When administered intravenously, the response is in about 5 minutes. 50 mg furosemide as a monoethanolamine salt, myristyl-gamma-picolinium chloride 0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with sodium chloride 0.2% in water for injection, p H adjusted with sodium hydroxide and/or hydrochloric acid. The therapeutic efficacy of Furosemide Injection is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. Effects of Intra-Arterially and Intravenously Administered Ethacrynic Acid and Furosemide on Cochlear N1 in Cats. The prompt onset of action is a result of the drug’s rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Furosemide has no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule.
What is Salix: Salix is the brand name product for the generic furosemide which is a loop diuretic. Salix can be used to increase water excretion in diseases such as heart disease, high blood pressure, pulmonary edema, and others. Salix works by increasing the amount of water that gets excreted through the kidneys and into the urine. What are the side effects of Salix: Salix can cause fluid and electrolyte abnormalities and you should monitor your pet’s food and water intake. It is less likely, but your pet may experience stomach disturbances, blood disturbances, weakness, and restlessness. Signs that your pet may be dehydrated or experiencing electrolyte abnormalities include excessive thirst, lethargy, restlessness, reduced urination, stomach distress, or a fast heart rate. If your pet experiences any of these symptoms while taking Salix you should consult your pet's veterinarian immediately. Using too much of this drug can lead to serious water and salt/mineral loss. Therefore, it is important that you are closely monitored by your doctor while taking this medication. Show More Furosemide is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. Tell your doctor right away if you become very thirsty or confused, or develop muscle cramps/weakness. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen. This drug is also used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Furosemide is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra water and salt.
Apr 26, 2018. Dilution Furosemide Lasix ®. The usual initial dose of furosemide is 20 mg to 40 mg given as a single dose. Source package insert. Lasix reference guide for safe and effective use from the American Society of. In prolonged diuretic therapy, intermittent use of the drug e.g. on 2–4.