Ciprofloxacin is active against a broad range of bacteria including both gram-negative & gram-positive bacteria, the most susceptible ones are the aerobic gram-negative bacilli, especially the Enterobacteriaceae and Neisseria. Ciprofloxacin is effective in a broad range of infections. Because of wide-spectrum bactericidal activity, oral efficacy and good tolerability, it is being extensively employed for blind therapy of any infection, but should not be used for minor cases or where gram-positive organisms and /or anaerobes are primarily causative. In severe infections, therapy may be initiated by i.v. Ciprofloxacin (Brand Name: Ciproxin)belongs to a group of broad-spectrum antimicrobial drugs known as fluoroquinolones. Ciproxin is used to treat bacterial infections, for example: It is rapidly absorbed orally, but the diet delays the intake and first-pass metabolism occur. It is the most active second generation fluoroquinolone against a wide range of bacteria that are susceptible to Gram-negative aerobic rods, especially the Enterobacteriaceae Neisseria. They must be combined with other tuberculosis drugs rifampicin and ethambutol. The key feature of ciprofloxacin is high tissue penetration. Ciprofloxacin is effective against Staphylococcus aureus and Staphylococcus epidermidis. Other Brands: Novidat Manufactured By Sami Pharmaceutical Pvt Limited. The concentration in the lungs, sputum, muscles, bones, prostate, and phagocytes exceeds that of the plasma. It is active against susceptible strains of Staphylococcus aureus and is not effective against Methicillin-Resistant Staphylococcus aureus. It is excreted mainly in the urine, both glomerular filtration and tubular secretion. Ciprofloxacin (Ciproxin) has a very good activity against gram-negative bacteria, but enterococci, Streptococcus group A, B, D and streptococcal viridans with moderate susceptibility to ciprofloxacin. Urinary and biliary concentrations are 10 to 50 times higher than those of plasma. It is also very effective against Mycobacterium tuberculosis and M. Ciprofloxacin ( Ciproxin ) inhibits the synthesis of DNA in microorganisms by inhibiting the bacterial topoisomerase enzyme DNA (DNA gyrase). Due to its broad spectrum, its oral effectiveness and its good tolerability, it is often used to treat infections, but should not be used for minor infections. in severe cases, treatment by intravenous infusion may be initiated, then continue with the oral.
Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide). Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant. This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Find information about common, infrequent and rare side effects of Cipro Oral. Ciprofloxacin can cause serious side effects, including tendon problems, side effects on your nerves which may cause permanent nerve damage, serious mood or behavior changes after just one dose, or low blood sugar which can lead to coma.