The antibiotic that's sold as Zithromax, Zmax or sometimes referred to as a "Z-Pack" is prescribed to treat bacterial infections such as bronchitis, pneumonia, or ear infections. The FDA is warning the public that the pills can cause abnormal changes in the heart's electrical activity that may lead to a fatal heart rhythm. Patients with known risk factors such as existing QT interval prolongation, low blood levels of potassium or magnesium, a slower than normal heart rate, or those who use certain drugs to treat abnormal heart rhythms, or arrhythmias face the greatest risk. "Health care professionals should consider the risk of fatal heart rhythms with azithromycin when considering treatment options for patients who are already at risk for cardiovascular events," the FDA said in its March 12th update. The new guidance was prompted by a May 2012 study and another study by the antibiotic's manufacturer, Pfizer, that looked at risks to electrical activity of the heart in azithromycin-takers. Last May, a New England Journal of Medicine study paid for by the National Heart, Lung and Blood Institute found there would be 47 extra heart-related deaths per one million course of treatment with five days of Zithromax, as compared to 10 days of amoxicillin and other antibiotics. The risks of cardiovascular death associated with levofloxacin (Levaquin) treatment were similar to those associated with azithromycin treatment, according to the FDA. "People need to recognize that the overall risk is low," Dr. It's widely used to treat chest infections such as pneumonia, infections of the nose and throat such as sinus infection (sinusitis), skin infections, Lyme disease, and some sexually transmitted infections. Azithromycin is used in children, often to treat ear infections or chest infections. It can also be used long term to prevent chest infections in people who keep getting them. The medicine is available on prescription as capsules, tablets and a liquid that you drink. It can also be given by injection, but this is usually only done in hospital. Azithromycin is usually taken once a day, unless you're having it by injection. Try to take your medicine at the same time each day.
Combination antibiotic treatment for community-acquired pneumonia in children is common, but a new study suggests that using just one of the two drugs is just as effective in most cases and can go a long way toward curbing the use of azithromycin, one of the most commonly used antibiotics in pediatric settings. A research team based at Vanderbilt University Medical Center (VUMC) reported their findings in a recent issue of . For most pneumonia infections, the causative agent is difficult to identify, and clinicians often prescribe empiric treatment. Amoxicillin, a beta lactam drug, treats the most common bacteria that cause pneumonia and according to national guidelines is the treatment of choice for most children with the disease. Azithromycin, a macrolide antibiotic, is often used to treat "atypical pneumonia," which can be more common in older children and adolescents, though the benefits of the drug aren't clear. The prospective observational study, part of a larger pneumonia etiology study, included 1,418 children hospitalized at three centers in Tennessee and Utah from January 2010 to June 2012 for radiologically confirmed pneumonia; 72% received just amoxicillin, while 28% were treated with both amoxicillin and azithromycin. Nearly 74% of the kids had a virus detected, with or without bacterial coinfection. Philippe Ovetchkine, Michael J Rieder; Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee Paediatr Child Health 2013;18(6):311-3 Azithromycin is an antibiotic that is commonly prescribed for upper and lower respiratory tract infections in children. While it has proven benefits, some concerns regarding azithromycin use have arisen in recent years. This practice point considers azithromycin therapy for acute respiratory infections in otherwise healthy children. Pharmacokinetics, spectrum of activity, the problem of resistant bacteria and clinical aspects are considered, along with recommendations for use and contraindications. Azithromycin should be avoided in patients with a significant risk of bacteremia. It is associated with pneumococcal resistance and, with stated exceptions, is generally not recommended for the treatment of acute pharyngitis, acute otitis media or pneumococcal community-acquired pneumonia in the paediatric population. Key Words: Antibiotics; Azithromycin; Infections; Macrolides; Resistance; Treatment Azithromycin, the first azalide from the macrolide class of antibiotics, has rapidly become one of the more common antibiotics prescribed by paediatricians, particularly for respiratory infections. Azithromycin is easily administered to children as an oral suspension, with once-a-day dosing for a relatively short treatment duration (three to five days) and a favourable side effect profile.
Jun 7, 2013. Azithromycin is an antibiotic that is commonly prescribed for upper and lower respiratory tract infections in children. While it has proven benefits. Find information about common, infrequent and rare side effects of Zithromax Oral.