Medication is often administered via drinking water. This allows the drug to be easily administered, ensures it can be accurately dosed, and the way of administration or the dosage can be easily adapted. The quality and features of the drinking water and the drinking water distribution system can, however, have an effect on the efficacy of the medicinal products. Groundwater quality can differ depending on the depth and region from where it is extracted. Even tap water, which has to meet strict quality standards, can vary in quality from region to region. These differences in quality can affect the solubility and the way in which the medications work (antibiotics and vaccinations). Water hardness is a measure of the concentration of metal ions – mostly magnesium and calcium carbonate, but also bicarbonates and sulphates – in the water. If the water hardness is high, there is a greater risk that these metals are present and so additional measures need to be taken before you can start any treatment with antibiotics in drinking water. As a member, you'll also get unlimited access to over 75,000 lessons in math, English, science, history, and more. Plus, get practice tests, quizzes, and personalized coaching to help you succeed. Try it risk-free Did you know that when you are prescribed a drug there may be more than one version of it? And, yes, that could mean a different brand name or a different dosage form, like a capsule versus a tablet. But it could also mean it's almost the same drug, simply a different salt of the drug. Find out as we discuss doxycycline hyclate versus doxycycline monohydrate in this lesson. First, let's quickly go over what doxycycline actually is. Doxycycline is a kind of antibiotic, a drug that targets bacteria, of the tetracycline class of antibiotics.
Doxycycline hydrochloride is the hydrochloride form of doxycycline, being a tetracycline antibiotic that has enjoyed widespread use in both veterinary and human medicine owing to its relatively broad spectrum and wide margin of safety. The first members of the tetracycline class were isolated from several species of bacteria from the genus Streptomyces in the1940s and 1950s. Since that time, a variety of tetracycline have been discovered, both naturally produced (e.g., chlortetracycline) and semisynthetic (e.g., doxycycline and tetracycline). Doxycycline was discovered in 1967 and has undergone extensive investigation, both for its antimicrobial properties as well as the effects it has on the physiology of higher organisms. Two different commercial doxycycline products are available for use in dogs; doxycycline hyclate tablets (Ronaxan; Merial) are available in several European countries, and doxycycline monohydrate paste or tablets (Vibra Vet; Pfizer) are available in other countries, including Australia, New Zealand, and South Africa. These products are used for treatment of respiratory tract infections and other infections caused by a variety of bacteria, including staphylococci. The development of tetracycline antibiotics was the result of a systematic screening of soil specimens collected from many parts of the world for antibiotic-producing organisms. The solubility of doxycycline monohydrate and doxycycline hydrochloride dihydrate was investigated in aqueous solution. The hydrochloride dihydrate salt was isolated and identified from solutions initially containing doxycycline hyclate in water. The p Ka' = 3.09 (μ = 0.1 and 25°) for protonation of doxycycline was determined spectro-photometrically. The p H-solubility profiles were determined for doxycycline monohydrate in water and in 1.0 and Na CI–HC1. The p H-solubility profile at 25° for doxycycline in aqueous hydrochloric acid without added salt reached a sharp maximum of 50 mg/ml at p H 2.16. Added chloride ion strongly suppressed the solubility of the hydrochloride dihydrate salt. The apparent solubility product was not constant but decreased as the concentration of added salt increased.
Mar 22, 2018. Their main important difference is in the fact that doxycycline hyclate is water soluble. It's easily mixable in water. In contrast, doxycycline. Density, Doxycycline hydrochloride more soluble than doxycycline. B135.44.w44. Water solubility, --. Other solubility, --. Acid/Base, Doxycycline hydrochloride.