Also known as: Catapres, Kapvay The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."For me, clonidine should be a very, very *last resort* medication for opiate withdrawal -- i.e., if absolutely nothing else is available. The reason is, clonidine actually intensifies one of the worst opiate withdrawal symptoms: mental depression & weakness. So basically I go from feeling like awful -to- feeling like double awful. And when (we) feel like double awful, then we want to 'use' (opiates) again. This is why clonidine has a very low "retention rate", vs. meds like Suboxone and methadone.""I have severe fibromyalgia and 7 years ago I needed a total knee replacement that’s when I started taking ocycodone 5mg and the amounts were getting higher. I had rapid heartbeat, my pressure elevated some, I was very dizzy and had dry mouth. Clonidine, sold as the brand name Catapres among others, is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. Clonidine is used to treat high blood pressure, attention deficit hyperactivity disorder (ADHD), drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. It can alleviate opioid withdrawal symptoms by reducing the sympathetic nervous system response such as tachycardia and hypertension, as well as reducing sweating, hot and cold flashes, and general restlessness. Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders. Clonidine has also been used to treat refractory diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, withdrawal-associated diarrhea, intestinal failure, neuroendocrine tumors and cholera. The reduction in circulating norepinephrine by clonidine was used in the past as an investigatory test for phaeochromocytoma, which is a catecholamine-synthesizing tumour, usually found in the adrenal medulla. In a clonidine suppression test plasma catecholamine levels are measured before and 3 hours after a 0.3 mg oral test dose has been given to the patient.
Clonidine is an antihypertensive drug originally synthesized in the early 1960s by chemists employed under the pharmaceutical company Boehringer Ingelheim. At the time, the chemists intended to develop a peripherally-active adrenergic nasal decongestant to be administered in the form of nose drops. In the process, the chemists sought to modify amidines to fit the chemical structure of imidazoline-derived decongestants, however, they encountered a challenging obstacle in which a methylene bridge needed to be replaced with nitrogen monohydride [at multiple positions (2- and 6-) of the phenyl ring]. For this to work, the chemists utilized chlorine atoms, ultimately leading to the synthesis of clonidine. After its synthesis, preliminary trials evaluated clonidine as a nasal decongestant, and at low doses, a decongestive response occurred. However, since hypotension was its most prominent effect, Boehringer Ingelheim shifted trials evaluating clonidine as a decongestant, to trials of clonidine as an antihypertensive agent. By 1966, clonidine had received FDA approval for the treatment of hypertension and became widely used among individuals with high blood pressure. One of the most persistent worries about detoxing from opioids is the discomfort of withdrawal symptoms. Body aches and pains, nausea, insomnia, and other symptoms can make it challenging for an individual to maintain abstinence long enough to fully eliminate the drug from the body, increasing the chance that the person will not complete treatment. To help avoid this problem, people often look to medicines to minimize withdrawal symptoms. Clonidine is one such medication that is used by treatment professionals to ease the discomfort of detox and give those who are struggling with opioid abuse a better chance at achieving recovery. According to Mental Health Daily, clonidine was originally developed as a nasal decongestant. After a while, it was found that it did better at helping to treat high blood pressure, and it largely became marketed for that. Then, after a number of years, doctors began using the medicine for off-label applications that it seemed to help with.
The symptoms of clonidine withdrawal are numerous and range from mild stomach upset to severe and dangerous increases in blood pressure. Additional effects are headaches, trouble sleeping, vision changes and flulike feelings. Patients may develop other troubling signs such as tremors, fever, hallucinations, and extreme anxiety. These reactions can be prevented by slowly tapering off the medication, and reintroducing the abruptly discontinued drug may stop severe symptoms. Generally, patients will only experience clonidine withdrawal if they suddenly stop taking the drug without guided tapering. This means anyone on this medication needs a doctor’s advice on how to discontinue it safely. It’s important to stress that even short term use can create withdrawal. In the same year, about 11.5 million people were nonmedical users of narcotic pain relievers. If you stop or cut back on these drugs after heavy use of a few weeks or more, you will have a number of symptoms. In 2016 in the United States, about 948,000 people used heroin during the past year. This means they were taking narcotics that were not prescribed to them. Narcotic pain relievers include: These drugs can cause physical dependence. This means that a person relies on the drug to prevent withdrawal symptoms. Over time, more of the drug is needed for the same effect. How long it takes to become physically dependent varies with each person. When the person stops taking the drugs, the body needs time to recover. Withdrawal from opiates can occur any time long-term use is stopped or cut back.
Clonidine is beneficial in opiate withdrawal because it treats symptoms that are commonly associated with that condition watery eyes and nose, diarrhea. These symptoms can be made worse if the drug was used along with other addictive substances, because those withdrawal symptoms will likely be present as well. Symptoms of Withdrawal Stopping the use of Clonidine always results in some type of withdrawal.