This medication should not be given to a patient without their knowledge. Do not take this medication if you are under the influence of alcohol or have drunk alcohol in the last 12 hours. Show More This medication is used along with counseling and support to treat alcoholism. Disulfiram works by blocking the processing of alcohol in the body. This causes you to have a bad reaction when you drink alcohol. Take this medication by mouth with or without food, usually once daily in the morning or as directed by your doctor. If this medication causes drowsiness, take it at bedtime. Dosage is based on your medical condition and response to therapy. The maximum recommended daily dose is 500 milligrams. It prohibits the activity of aldehyde dehydrogenase, an enzyme found in the liver. In the United States, disulfiram is sold under brand name Antabuse. Disulfiram is used as a conditioning treatment for alcohol dependence. When taken with alcohol, disulfiram causes many unwanted and unpleasant effects, and the fear of these is meant to condition the patient to avoid alcohol. Two Danish physicians who were investigating disulfiram for its potential benefits to destroy parasitic worms took disulfiram and became sick at a cocktail party. After a series of pharmacological and clinical studies, it was determined that disulfiram interacts with alcohol. If taken with alcohol, however, it alters certain steps in the breakdown of alcohol. When alcohol is ingested, it is converted first to a chemical called acetaldehyde. In order for acetaldehyde to be broken down into acetate, aldehyde dehydrogenase needs to be active. Since disulfiram blocks the activity of aldehyde dehydrogenase, acetaldehyde cannot be broken down and the levels of acetaldehyde become five to ten times higher than the normal levels.
El Americanismo.- Llamado también jerga, o lo que dicen palabras bulgares, es que todo lo que no está en el diccionario español. Lo que pasa es que cada país, tiene su lenguaje propio según el idioma ancestral que han tenido como origen racial o étnica. Fifty-two healthy volunteers, 29 men and 23 women, aged 20-61 years, were treated with increasing doses of Antabuse 1, 100, 200, 300 mg for 14 days each.