Clonidine is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk for heart attacks. These problems may be less likely to occur if the blood pressure is controlled. Clonidine belongs to the class of medicines called antihypertensives. • Abrupt withdrawal of adrenergic blockers in a hypertensive subject may result In acute hypertensive crisis. This crisis results from marked increase in adrenergic discharge and upregulation of adrenoceptors. In a patient with hypertensive crisis following abrupt cessation of clonidine hydrochloride and metoprolol tartrate, intravenous administration of labetalol hydrochloride rapidly reduced blood pressure and heart rate to precrisis levels. The patient was subsequently maintained in a normotensive state by continued oral use of labetalol.
We take many different medications over the course of our lives with little thought as to how they work. This lesson covers the mechanism of action of clonidine as well as its interactions with other drugs. Assume that migraines have been a painful part of your life for a really long time. The difference, however, is that they are now worse than before. This prompts your doctor to prescribe a different medication to help manage your migraines. Clonidine, a medication that helps to stimulate the hypothalamus to reduce blood pressure, is the newest weapon you are given to help prevent migraines. You find it interesting that a medication for lowering blood pressure can be used to relieve your migraines. Clonidine and beta-blockers have been used to treat the hyperadrenergic state of alcohol withdrawal. Although these agents may correct some of the autonomic manifestations of withdrawal, they have not been demonstrated to have any effect on seizures or DTs, and they should be used only in conjunction with benzodiazepines in the treatment of patients with alcohol withdrawal. The recommended dose for clonidine is 0.2 mg orally bid, but this dose should be individualized. Beta-blockers may obscure the vital sign abnormalities that occur early in alcohol withdrawal and prevent early recognition of more severe alcohol withdrawal. They should not be used alone, but only when combined with adequate sedative-hypnotic drug therapy. Beta-blockers that have been recommended include atenolol, metoprolol, propranolol, and labetalol. The usual contraindications for clonidine and beta-blockers apply.
The risk of cardiovascular and fatal complications and the antihypertensive effect of a clonidine-β-blocker combination was studied in 98 patients and was compared with the results for a group of patients treated with other antihypertensive regimens. The profile of complications was similar in the two groups for a total follow-up period of more than 2000 treatment-months. Clonidine in combination either with propranolol or atenolol had a distinct antihypertensive effect. However, clonidine plus atenolol resulted in a more immediate and pronounced fall in blood pressure. It is concluded that the combination of clonidine and a β-blocker is an effective antihypertensive medication, and that patients treated with it are apparently at no greater risk of serious cardiovascular incidents than are those treated with other regimens. Theres no otc pain relievers that Im aware of that have negative interaction with clonidine, and yes you can take immodium. I take clonidine still to this day for my blood pressure and I use naproxen, aspirin,tylenol etc. and I was taking immodium during my detox while on clonidine. If you want to be safe go to and look up clonidine and it will tell you all the possible interactions it can have. As far as I know there shouldnt be anything to worry about. Amiloride hydrochloride - Midamor Bumetanide - Bumex Ethacrynic acid - Edecrin Furosemide - Lasix Spironolactone - Aldactone Torsemide - Demadex Triamterene - Dyrenium Beta-blockers Beta blockers block the effect of adrenaline on the cardiovascular system, slow the heart rate, and reduce stress on the heart and the arteries. This was a major issue for me because my docs and pharmacist set a lower limit as to how low I was allowed to let my BP get with the beta blocker, and it consistently would push mine under that so I wouldn't be able to take it; I don't always have orthostatic hypotension (i.e.
You may be at higher risk for a rise in blood pressure if you are taking clonidine in large doses or if you are taking it along with another blood pressure medication called a beta-blocker. In. Abrupt withdrawal of adrenergic blockers in a hypertensive subject may. clonidine withdrawal with blood pressure overshoot exaggerated by beta blockade.