Received date: November 02, 2016; Accepted date: December 06, 2016; Published date: December 06, 2016 Citation: Garreton AS, Valzacchi GR, Layus O, Matusevich L, Gueglio G (2016) Post-Finasteride Syndrome: About 2 Cases and Review of the Literature. doi: 10.4172/2167-0250.1000170 Copyright: © 2016 Garreton AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Visit for more related articles at Andrology-Open Access Introduction: Finasteride is widely used in the treatment of benign prostatic hyperplasia and androgenetic alopecia. Persistent sexual adverse events in patients that withdraw the drug was poorly studied. Materials and methods: case report study of two clinical cases of post-finasteride syndrome. Case 1: 27 year old male who, after 7 months of finasteride 1mg/day intake for androgenetic alopecia, began with erectile dysfunction, low libido, hypospermia, muscular hipotrophy and penile shrinking, in a persistent and progressive way although withdrawal of the drug. Case 2: 23 year old male that after the intake of 1 pill of finasteride 1mg for androgenetic alopecia began with erectile dysfunction, low libido, hypospermia, less intense orgasms, asthenia, muscle pain and penile shrinking, in a persistent and progressive way although withdrawal of the drug. Results: Case 1: Hormonal profiles were normal, with a dihydrotestosterone of 192 pg/ml and the penile ultrasound showed an hyperechogenicity at the distal portion of the right corpus cavernosum. The genetic determination of the CAG triplets of the androgen receptor gene showed a value of 24 repetitions. Physicians sometimes prescribe finasteride for the treatment of benign prostatic hyperplasia (BPH), informally known as an enlarged prostate. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start and end of urination, and decreased urinary flow. It provides less symptomatic relief than alpha-1 blockers such as tamsulosin and symptomatic relief is slower in onset (six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment). Symptomatic benefits are mainly seen in those with prostate volume . In long-term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention (−57% at 4 years) and the need for surgery (−54% at 4 years). If the drug is discontinued, any therapeutic benefits are reversed within about 6–8 months. A followup study of the Medicare claims of participants in a 10-year Prostate Cancer Prevention Trial suggests a significant reduction in prostate cancer risk is maintained even after discontinuation of treatment.
IF YOU'RE A BIG TEN SPORTS FAN, you've probably seen Charles K. moving up and down the Big House field during Michigan home games. The now 31-year-old didn't play football—he played sax in the Wolverine marching band. Early on, Charles was a "shy band nerd," but over the course of his college career he morphed into another kind of player. "By my senior year," he concedes, "I'd earned something of a reputation among my friends for dating multiple girls at once." After graduating and moving to Chicago, Charles planned on playing the field for at least a few more years. But then something happened that he hadn't counted on: His hair started falling out. "Here I was, a single guy just starting life in the big city, and I was going bald. I kept thinking, " Charles decided to start taking Propecia, the only FDA-approved oral medication for male-pattern baldness. Finasteride is a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (eg, Propecia, Profal and Re Gen) or enlarged prostate (eg, Proscar, Finasteride Rex and Fintral). PFS includes sexual, physical, and mental and neurological symptoms in patients who have taken finasteride (Table 1). Symptoms often persist after the patient has stopped taking finasteride. Table 1: Reported symptoms of Post-Finasteride Syndrome Importantly, some patients can experience suicidal ideation and depression after stopping finasteride treatment. Patients and their families should be advised about these symptoms and to seek medical advice as soon as possible if they occur. Unfortunately, PFS is a condition with no known cure and few, if any, effective treatments. Further information about PFS can be found on the Post-Finasteride Syndrome Foundation website (
The Post-Finasteride Syndrome Foundation's primary mission is to fund research. Interestingly, at the withdrawal, some of these effects persisted, and different. A I have just stopped taking Propecia about 2 weeks ago and I am getting headaches is this a withdrawal symptom? Headaches can be.