Metformin (Glucophage TM) is an anti-diabetic biguanide drug which has recently been introduced in the United States for the treatment of non-insulin-dependent diabetes (Type II diabetes). In addition to its promise in treating diabetes, I believe that Metformin is one of the most promising anti-aging, life extending drugs available! Metformin is chemically very similar to Phenformin, an anti-diabetic drug which was discontinued in the United States by the FDA in 1976. The reason for Phenformin’s removal from the market was because of a number of excess deaths in diabetic patients, caused by lactic acidosis. These deaths were invariably due to the continued use of phenformin by diabetics who had compromised kidney or liver function. No deaths were ever reported in patients who had normal kidney and liver function. Phenformin’s removal from the market was greatly lamented by most diabetologists at the time, one of whom once told me, “Phenformin did everything! N a Thursday evening in late January, the faithful gather. They trickle into the Church of Perpetual Life, about an hour’s drive north of Miami, until a throng of around 100 people cram around tables lining the first-floor hall of this renovated house of worship. Along one wall is a display of reading material: pamphlets on heart disease, flyers itemizing the additives in Cheez-Its and their detrimental health effects, a handbill about the Ms. On the other side of the room, there’s a snack buffet with beans, broccoli, carrots, cubed cheese, sliced meats, and olives. It’s easy to pick out the regulars, who mingle clutching biology textbooks or readily shaking hands. Many of them pause to greet the diminutive man who is their host: Bill Faloon. Clean-shaven and youthfully slim in a dark suit, with jet-black hair and a formidably bridged nose, he is the church’s founder. Just yesterday, he laid out its gospel to me, saying, “We’re talking about immortality.” His followers, he says, are “people trying to live as long as possible, maybe even forever.” At 63, Faloon is old enough to remember when such talk labeled you a kook or charlatan.
Metformin is an FDA-approved drug that has been used for over 60 years to treat type 2 diabetes. In recent years, metformin has been shown to extend the lifespan in some animal models. However, whether metformin can suppress human cellular aging and the mechanisms underlying its probable effects in humans remain unclear. In the present study, a team of researchers led by Professors Wang Chihchen and Liu Guanghui at the Institute of Biophysics of Chinese Academy of Sciences (CAS) found that chronic low-dose metformin treatment delays aging in human cells, specifically diploid fibroblasts and mesenchymal stem cells. Previous research by the same group showed that a protein called endoplasmic reticulum-localized glutathione peroxidase 7 (GPx7) is a key enzyme involved in regulating protein folding and maintaining redox homeostasis. The researchers found that low-dose metformin treatment upregulates the expression of endoplasmic reticulum-localized GPx7 by activating a transcription factor called Nrf2. The levels of GPx7 decrease as cells age and knocking down GPx7 accelerated the process of aging, the researchers said. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging(ref). In fact, it is probably the pharmaceutical most used for this purpose. The purpose of this blog entry is to discuss Metformin as it has been shown to reduce all cause mortality in various studies, and discuss its understood mechanisms of operation. This blog entry is Part 2 of interventions that reduce all cause mortality. Metformin is a traditional and inexpensive drug that is the first line of treatment for people with Type 2 Diabetes or prediabetic conditions. The first blog entry in this series, which was also Part 4 of the inflammation series. It is a drug that has been extensively studied, both with respect to the impacts of using it and as to the molecular mechanisms of its operations. Image source Metformin “originates from the French lilac or ”“Metformin has been used for over 40 years as an effective glucose-lowering agent in type 2 DM. Typically it reduces both basal and post-prandial hyperglycaemia by about 25-30% on over 90% of type 2 DM patients when given either alone or in combination with other therapies —”(ref)Clinical trials of Metformin Clinical lists 1989 clinical trials mentioning Metformin but only three clinical trials mentioning Metformin and longevity. One is called the Metformin in Longevity Study (MILES)sponsored by the Albert Einstein College of Medicine is currently listed as active but not recruiting and is the only study where aging is the unique endpoint condition.
Metformin, an FDA approved first-line drug for the treatment of type 2 diabetes, has known beneficial effects on glucose metabolism. Evidence from animal. Apr 27, 2018. In recent years, metformin has been shown to extend the lifespan in. for the positive effects of metformin on life span extension in worms.